Neuroscience - Endocannabinoid signaling in the brain

被引：941
作者：
Wilson, RI
Nicoll, RA
机构：
[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
[3] CALTECH, Div Biol, Pasadena, CA 91125 USA
来源：
SCIENCE | 2002年 / 296卷 / 5568期
关键词：
D O I：
10.1126/science.1063545
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The primary psychoactive ingredient in cannabis, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), affects the brain mainly by activating a specific receptor (CB1). CB1 is expressed at high levels in many brain regions, and several endogenous brain lipids have been identified as CB1 ligands. In contrast to classical neurotransmitters, endogenous cannabinoids can function as retrograde synaptic messengers: They are released from postsynaptic neurons and travel backward across synapses, activating CB1 on presynaptic axons and suppressing neurotransmitter release. Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism.
引用
收藏
页码：678 / 682
页数：5
相关论文
共 77 条
[1]   Interactions between distinct GABAA circuits in hippocampus [J].
Banks, MI ;
White, JA ;
Pearce, RA .
NEURON, 2000, 25 (02) :449-457
[2]   Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids [J].
Beinfeld, MC ;
Connolly, K .
NEUROSCIENCE LETTERS, 2001, 301 (01) :69-71
[3]   Functional role of high-affinity anandamide transport, as revealed by selective inhibition [J].
Beltramo, M ;
Stella, N ;
Calignano, A ;
Lin, SY ;
Makriyannis, A ;
Piomelli, D .
SCIENCE, 1997, 277 (5329) :1094-1097
[4]   Brain regional distribution of endocannabinoids: Implications for their biosynthesis and biological function [J].
Bisogno, T ;
Berrendero, F ;
Ambrosino, G ;
Cebeira, M ;
Ramos, JA ;
Fernandez-Ruiz, JJ ;
Di Marzo, V .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 256 (02) :377-380
[5]   Evidence for a new G protein-coupled cannabinoid receptor in mouse brain [J].
Breivogel, CS ;
Griffin, G ;
Di Marzo, V ;
Martin, BR .
MOLECULAR PHARMACOLOGY, 2001, 60 (01) :155-163
[6]  
Brodkin J, 1997, J PHARMACOL EXP THER, V282, P1526
[7]   TEMPORAL STRUCTURE IN SPATIALLY ORGANIZED NEURONAL ENSEMBLES - A ROLE FOR INTERNEURONAL NETWORKS [J].
BUZSAKI, G ;
CHROBAK, JJ .
CURRENT OPINION IN NEUROBIOLOGY, 1995, 5 (04) :504-510
[8]   Potentiation of anandamide hypotension by the transport inhibitor, AM404 [J].
Calignano, A ;
LaRana, G ;
Beltramo, M ;
Makriyannis, A ;
Piomelli, D .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 337 (01) :R1-R2
[9]  
Compton DR, 1996, J PHARMACOL EXP THER, V277, P586
[10]   Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase [J].
Cravatt, BF ;
Demarest, K ;
Patricelli, MP ;
Bracey, MH ;
Giang, DK ;
Martin, BR ;
Lichtman, AH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) :9371-9376
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