Surface architecture of Histoplasma capsulatum

被引:46
作者
Guimaraes, Allan J. [1 ,2 ]
de Cerqueira, Mariana D. [3 ]
Nosanchuk, Joshua D. [1 ,4 ]
机构
[1] Yeshiva Univ Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
[2] Univ Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Dept Imunol, BR-21941902 Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Dept Microbiol Geral, BR-21941902 Rio De Janeiro, Brazil
[4] Yeshiva Univ Albert Einstein Coll Med, Dept Med, Div Infect Dis, Bronx, NY 10461 USA
关键词
Histoplasma capsulatum; surface; cell wall; architecture; proteins; carbohydrates; PHOSPHOINOSITOL-CONTAINING SPHINGOLIPIDS; YEAST-CELL WALL; PARACOCCIDIOIDES-BRASILIENSIS; CRYPTOCOCCUS-NEOFORMANS; BLASTOMYCES-DERMATITIDIS; MONOCLONAL-ANTIBODY; IMMUNE-RESPONSES; BETA-GLUCAN; H-ANTIGEN; PATHOGENIC FUNGUS;
D O I
10.3389/fmicb.2011.00225
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The dimorphic fungal pathogen Histoplasma capsulatum is the most frequent cause of clinically significant fungal pneumonia in humans. H. capsulatum virulence is achieved, in part, through diverse and dynamic alterations to the fungal cell surface. Surface components associated with H. capsulatum pathogenicity include carbohydrates, lipids, proteins, and melanins. Here, we describe the various structures comprising the cell surface of H. capsulatum that have been associated with virulence and discuss their involvement in the pathobiology of disease.
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页数:14
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