A novel Germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men

被引：74

作者：

Lin, Xiaoling ^{[1
,2
]}

Qu, Lianxi ^{[2
]}

Chen, Zhuo ^{[3
]}

Xu, Chuanliang ^{[4
]}

Ye, Dingwei ^{[5
,6
]}

Shao, Qiang ^{[7
]}

Wang, Xiang ^{[2
]}

Qi, Jun ^{[8
]}

Chen, Zhiwen ^{[9
]}

Zhou, Fangjian ^{[10
,11
]}

Wang, Meilin ^{[12
]}

Wang, Zhong ^{[13
]}

He, Dalin ^{[14
]}

Wu, Denglong ^{[15
]}

Gao, Xin ^{[16
]}

Yuan, Jianlin ^{[17
]}

Wang, Gongxian ^{[18
]}

Xu, Yong ^{[19
]}

Wang, Guozeng ^{[20
]}

Dong, Pei ^{[10
,11
]}

Jiao, Yang ^{[8
]}

Yang, Jin ^{[21
]}

Jun Ou-Yang ^{[22
]}

Jiang, Haowen ^{[2
]}

Zhu, Yao ^{[5
,6
]}

Ren, Shancheng ^{[4
]}

Zhang, Zhengdong ^{[12
]}

Yin, Changjun ^{[23
]}

Wu, Qijun ^{[24
]}

Zheng, Ying ^{[25
]}

Turner, Aubrey R. ^{[3
]}

Tao, Sha ^{[3
]}

Na, Rong ^{[2
,3
]}

Ding, Qiang ^{[2
]}

Lu, Daru ^{[1
,26
]}

Shi, Rong ^{[27
]}

Sun, Jielin ^{[3
]}

Liu, Fang ^{[1
,2
]}

Zheng, S. Lilly ^{[3
]}

Mo, Zengnan ^{[28
,29
]}

Sun, Yinghao ^{[4
]}

Xu, Jianfeng ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Sch Life Sci, Fudan VARI Ctr Genet Epidemiol, Shanghai 200040, Peoples R China

[2] Fudan Univ, Fudan Inst Urol, Huashan Hosp, Shanghai 200040, Peoples R China

[3] Wake Forest Univ, Bowman Gray Sch Med, Ctr Canc Genom, Winston Salem, NC USA

[4] Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai, Peoples R China

[5] Fudan Univ, Canc Hosp, Dept Urol, Shanghai 200040, Peoples R China

[6] Fudan Univ, Shanghai Med Coll, Dept Urol, Shanghai 200040, Peoples R China

[7] Suzhou Municipal Hosp, Dept Urol, Suzhou, Peoples R China

[8] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Urol, Shanghai 200030, Peoples R China

[9] Third Mil Med Univ, Southwest Hosp, Urol Inst PLA, Chongqing, Peoples R China

[10] State Key Lab Oncol So China, Guangzhou, Peoples R China

[11] Sun Yat Sen Univ, Ctr Canc, Dept Urol, Guangzhou 510275, Guangdong, Peoples R China

[12] Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Key Lab Modern Toxicol,Dept Mol & Genet Toxicol, Nanjing, Jiangsu, Peoples R China

[13] Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Urol, Shanghai 200030, Peoples R China

[14] Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Urol, Xian 710049, Peoples R China

[15] Tongji Univ, Tongji Hosp, Dept Urol, Shanghai 200092, Peoples R China

[16] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Urol, Guangzhou 510275, Guangdong, Peoples R China

[17] Forth Mil Med Univ, Xijing Hosp, Dept Urol, Xian, Shaanxi Provinc, Peoples R China

[18] Nanchang Univ, Affiliated Hosp 1, Dept Urol, Nanchang, Jiangxi, Peoples R China

[19] TianJin Med Univ, Hosp 2, TianJin Inst Urol, Dept Urol, Tianjin, Peoples R China

[20] Pudong Gongli Hosp, Dept Urol, Shanghai, Peoples R China

[21] Third Mil Med Univ, Dept Cell Biol, Chongqing, Peoples R China

[22] Suzhou Univ, Peoples Hosp 1, Dept Urol, Suzhou 215006, Peoples R China

[23] Nanjing Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing, Jiangsu, Peoples R China

[24] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Shanghai Canc Inst,State Key Lab Oncogene & Relat, Shanghai 200030, Peoples R China

[25] Shanghai Ctr Dis Control & Prevent, Shanghai, Peoples R China

[26] Fudan Univ, Sch Life Sci, Key Lab Contemporary Anthropol, State Key Lab Genet Engn, Shanghai 200040, Peoples R China

[27] Shanghai Jiao Tong Univ, Sch Publ Hlth, Shanghai 200030, Peoples R China

[28] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning, Guangxi, Peoples R China

[29] Guangxi Med Univ, Affiliated Hosp 1, Dept Urol & Nephrol, Nanning, Guangxi, Peoples R China

来源：

PROSTATE | 2013年 / 73卷 / 02期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

HOXB13; G135E; G84E; prostate cancer; Chinese; rare mutation; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; SEQUENCE VARIANTS; REPLICATION; PROTEINS; HOXA13; GENE;

D O I：

10.1002/pros.22552

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND A rare mutation G84E in HOXB13 was recently identified to be associated with prostate cancer (PCa) in Caucasians. The goal of this study is to test association between HOXB13 genetic variants and PCa risk in Chinese men. METHODS All study subjects were part of the Chinese Consortium for Prostate Cancer Genetics (ChinaPCa). In the first stage, we screened for mutations by sequencing the HOXB13 coding region in 96 unrelated PCa patients. In stage 2, G84E and novel mutations found in stage 1 were genotyped in 671 PCa patients and 1,536 controls. In stage 3, mutation status in 751 additional PCa patients was imputed via haplotype. RESULTS The G84E mutation was not detected in this study. However, a novel mutation, G135E, was identified among 96 patients in stage 1. It was also observed twice in 575 additional PCa patients but not in 1,536 control subjects of stage 2. The frequency of G135E was significantly different between cases and controls, with a P-value of 0.027, based on Fisher's exact test. Haplotype estimation showed that G135E mutation carriers shared a unique haplotype that was not observed in other subjects. In stage 3, two more PCa patients were predicted to carry the G135E mutation. CONCLUSIONS We identified a novel rare mutation in the HOXB13 gene, G135E, which appears to be a founder mutation. This mutation is associated with increased PCa risk in Chinese men. Consistent with a previous report, our findings provide further evidence that rare mutations in HOXB13 contribute to PCa risk. Prostate 73: 169175, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

页码：169 / 175

页数：7

共 28 条

[1] A method and server for predicting damaging missense mutations [J].

Adzhubei, Ivan A. ;

Schmidt, Steffen ;

Peshkin, Leonid ;

Ramensky, Vasily E. ;

Gerasimova, Anna ;

Bork, Peer ;

Kondrashov, Alexey S. ;

Sunyaev, Shamil R. .

NATURE METHODS, 2010, 7 (04) :248-249

[2] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[3] Predicting the insurgence of human genetic diseases associated to single point protein mutations with support vector machines and evolutionary information [J].

Capriotti, E. ;

Calabrese, R. ;

Casadio, R. .

BIOINFORMATICS, 2006, 22 (22) :2729-2734

[4] Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB21P [J].

Duggan, David ;

Zheng, Siqun L. ;

Knowlton, Michele ;

Benitez, Debbie ;

Dimitrov, Latchezar ;

Wiklund, Fredrik ;

Robbins, Christiane ;

Isaacs, Sarah D. ;

Cheng, Yu ;

Li, Ge ;

Sun, Jielin ;

Chang, Bao-Li ;

Marovich, Leslie ;

Wiley, Kathleen E. ;

Balter, Katarina ;

Stattin, Par ;

Adami, Hans-Olov ;

Gielzak, Marta ;

Yan, Guifang ;

Sauvageot, Jurga ;

Liu, Wennuan ;

Kim, Jin Woo ;

Bleecker, Eugene R. ;

Meyers, Deborah A. ;

Trock, Bruce J. ;

Partin, Alan W. ;

Walsh, Patrick C. ;

Isaacs, William B. ;

Gronberg, Henrik ;

Xu, Jianfeng ;

Carpten, John D. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (24) :1836-1844

[5] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[6] Identification of seven new prostate cancer susceptibility loci through a genome-wide association study [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Al Olama, Ali Amin ;

Giles, Graham G. ;

Guy, Michelle ;

Severi, Gianluca ;

Muir, Kenneth ;

Hopper, John L. ;

Henderson, Brian E. ;

Haiman, Christopher A. ;

Schleutker, Johanna ;

Hamdy, Freddie C. ;

Neal, David E. ;

Donovan, Jenny L. ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Ingles, Sue A. ;

John, Esther M. ;

Thibodeau, Stephen N. ;

Schaid, Daniel ;

Park, Jong Y. ;

Spurdle, Amanda ;

Clements, Judith ;

Dickinson, Joanne L. ;

Maier, Christiane ;

Vogel, Walther ;

Doerk, Thilo ;

Rebbeck, Timothy R. ;

Cooney, Kathleen A. ;

Cannon-Albright, Lisa ;

Chappuis, Pierre O. ;

Hutter, Pierre ;

Zeegers, Maurice ;

Kaneva, Radka ;

Zhang, Hong-Wei ;

Lu, Yong-Jie ;

Foulkes, William D. ;

English, Dallas R. ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Morrison, Jonathan ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Saunders, Edward J. ;

Page, Elizabeth C. ;

Sawyer, Emma J. ;

Edwards, Stephen M. ;

Dearnaley, David P. .

NATURE GENETICS, 2009, 41 (10) :1116-U97

[7] Germline Mutations in HOXB13 and Prostate-Cancer Risk [J].

Ewing, Charles M. ;

Ray, Anna M. ;

Lange, Ethan M. ;

Zuhlke, Kimberly A. ;

Robbins, Christiane M. ;

Tembe, Waibhav D. ;

Wiley, Kathleen E. ;

Isaacs, Sarah D. ;

Johng, Dorhyun ;

Wang, Yunfei ;

Bizon, Chris ;

Yan, Guifang ;

Gielzak, Marta ;

Partin, Alan W. ;

Shanmugam, Vijayalakshmi ;

Izatt, Tyler ;

Sinari, Shripad ;

Craig, David W. ;

Zheng, S. Lilly ;

Walsh, Patrick C. ;

Montie, James E. ;

Xu, Jianfeng ;

Carpten, John D. ;

Isaacs, William B. ;

Cooney, Kathleen A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (02) :141-149

[8] Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Manolescu, Andrei ;

Gudbjartsson, Daniel ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Blondal, Thorarinn ;

Jakobsdottir, Margret ;

Stacey, Simon N. ;

Kostic, Jelena ;

Kristinsson, Kari T. ;

Birgisdottir, Birgitta ;

Ghosh, Shyamali ;

Magnusdottir, Droplaug N. ;

Thorlacius, Steinunn ;

Thorleifsson, Gudmar ;

Zheng, S. Lilly ;

Sun, Jielin ;

Chang, Bao-Li ;

Elmore, J. Bradford ;

Breyer, Joan P. ;

McReynolds, Kate M. ;

Bradley, Kevin M. ;

Yaspan, Brian L. ;

Wiklund, Fredrik ;

Stattin, Par ;

Lindstrom, Sara ;

Adami, Hans-Olov ;

McDonnell, Shannon K. ;

Schaid, Daniel J. ;

Cunningham, Julie M. ;

Wang, Liang ;

Cerhan, James R. ;

St Sauver, Jennifer L. ;

Isaacs, Sara D. ;

Wiley, Kathleen E. ;

Partin, Alan W. ;

Walsh, Patrick C. ;

Polo, Sonia ;

Ruiz-Echarri, Manuel ;

Navarrete, Sebastian ;

Fuertes, Fernando ;

Saez, Berta ;

Godino, Javier ;

Weijerman, Philip C. ;

Swinkels, Dorine W. ;

Aben, Katja K. .

NATURE GENETICS, 2008, 40 (03) :281-283

[9] Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Steinthorsdottir, Valgerdur ;

Bergthorsson, Jon T. ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Rafnar, Thorunn ;

Gudbjartsson, Daniel ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Blondal, Thorarinn ;

Stacey, Simon N. ;

Helgason, Agnar ;

Gunnarsdottir, Steinunn ;

Olafsdottir, Adalheidur ;

Kristinsson, Kari T. ;

Birgisdottir, Birgitta ;

Ghosh, Shyamali ;

Thorlacius, Steinunn ;

Magnusdottir, Dana ;

Stefansdottir, Gerdur ;

Kristjansson, Kristleifur ;

Bagger, Yu ;

Wilensky, Robert L. ;

Reilly, Muredach P. ;

Morris, Andrew D. ;

Kimber, Charlotte H. ;

Adeyemo, Adebowale ;

Chen, Yuanxiu ;

Zhou, Jie ;

So, Wing-Yee ;

Tong, Peter C. Y. ;

Ng, Maggie C. Y. ;

Hansen, Torben ;

Andersen, Gitte ;

Borch-Johnsen, Knut ;

Jorgensen, Torben ;

Tres, Alejandro ;

Fuertes, Fernando ;

Ruiz-Echarri, Manuel ;

Asin, Laura ;

Saez, Berta ;

van Boven, Erica ;

Klaver, Siem ;

Swinkels, Dorine W. ;

Aben, Katja K. ;

Graif, Theresa .

NATURE GENETICS, 2007, 39 (08) :977-983

[10] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

Isaacs, William B. ;

Catalona, William J. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine .

NATURE GENETICS, 2007, 39 (05) :631-637

← 1 2 3 →

共 28 条

[1] A method and server for predicting damaging missense mutations [J].

Adzhubei, Ivan A. ;

Schmidt, Steffen ;

Peshkin, Leonid ;

Ramensky, Vasily E. ;

Gerasimova, Anna ;

Bork, Peer ;

Kondrashov, Alexey S. ;

Sunyaev, Shamil R. .

NATURE METHODS, 2010, 7 (04) :248-249

[2] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[3] Predicting the insurgence of human genetic diseases associated to single point protein mutations with support vector machines and evolutionary information [J].

Capriotti, E. ;

Calabrese, R. ;

Casadio, R. .

BIOINFORMATICS, 2006, 22 (22) :2729-2734

[4] Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB21P [J].

Duggan, David ;

Zheng, Siqun L. ;

Knowlton, Michele ;

Benitez, Debbie ;

Dimitrov, Latchezar ;

Wiklund, Fredrik ;

Robbins, Christiane ;

Isaacs, Sarah D. ;

Cheng, Yu ;

Li, Ge ;

Sun, Jielin ;

Chang, Bao-Li ;

Marovich, Leslie ;

Wiley, Kathleen E. ;

Balter, Katarina ;

Stattin, Par ;

Adami, Hans-Olov ;

Gielzak, Marta ;

Yan, Guifang ;

Sauvageot, Jurga ;

Liu, Wennuan ;

Kim, Jin Woo ;

Bleecker, Eugene R. ;

Meyers, Deborah A. ;

Trock, Bruce J. ;

Partin, Alan W. ;

Walsh, Patrick C. ;

Isaacs, William B. ;

Gronberg, Henrik ;

Xu, Jianfeng ;

Carpten, John D. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (24) :1836-1844

[5] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[6] Identification of seven new prostate cancer susceptibility loci through a genome-wide association study [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Al Olama, Ali Amin ;

Giles, Graham G. ;

Guy, Michelle ;

Severi, Gianluca ;

Muir, Kenneth ;

Hopper, John L. ;

Henderson, Brian E. ;

Haiman, Christopher A. ;

Schleutker, Johanna ;

Hamdy, Freddie C. ;

Neal, David E. ;

Donovan, Jenny L. ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Ingles, Sue A. ;

John, Esther M. ;

Thibodeau, Stephen N. ;

Schaid, Daniel ;

Park, Jong Y. ;

Spurdle, Amanda ;

Clements, Judith ;

Dickinson, Joanne L. ;

Maier, Christiane ;

Vogel, Walther ;

Doerk, Thilo ;

Rebbeck, Timothy R. ;

Cooney, Kathleen A. ;

Cannon-Albright, Lisa ;

Chappuis, Pierre O. ;

Hutter, Pierre ;

Zeegers, Maurice ;

Kaneva, Radka ;

Zhang, Hong-Wei ;

Lu, Yong-Jie ;

Foulkes, William D. ;

English, Dallas R. ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Morrison, Jonathan ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Saunders, Edward J. ;

Page, Elizabeth C. ;

Sawyer, Emma J. ;

Edwards, Stephen M. ;

Dearnaley, David P. .

NATURE GENETICS, 2009, 41 (10) :1116-U97

[7] Germline Mutations in HOXB13 and Prostate-Cancer Risk [J].

Ewing, Charles M. ;

Ray, Anna M. ;

Lange, Ethan M. ;

Zuhlke, Kimberly A. ;

Robbins, Christiane M. ;

Tembe, Waibhav D. ;

Wiley, Kathleen E. ;

Isaacs, Sarah D. ;

Johng, Dorhyun ;

Wang, Yunfei ;

Bizon, Chris ;

Yan, Guifang ;

Gielzak, Marta ;

Partin, Alan W. ;

Shanmugam, Vijayalakshmi ;

Izatt, Tyler ;

Sinari, Shripad ;

Craig, David W. ;

Zheng, S. Lilly ;

Walsh, Patrick C. ;

Montie, James E. ;

Xu, Jianfeng ;

Carpten, John D. ;

Isaacs, William B. ;

Cooney, Kathleen A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (02) :141-149

[8] Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Manolescu, Andrei ;

Gudbjartsson, Daniel ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Blondal, Thorarinn ;

Jakobsdottir, Margret ;

Stacey, Simon N. ;

Kostic, Jelena ;

Kristinsson, Kari T. ;

Birgisdottir, Birgitta ;

Ghosh, Shyamali ;

Magnusdottir, Droplaug N. ;

Thorlacius, Steinunn ;

Thorleifsson, Gudmar ;

Zheng, S. Lilly ;

Sun, Jielin ;

Chang, Bao-Li ;

Elmore, J. Bradford ;

Breyer, Joan P. ;

McReynolds, Kate M. ;

Bradley, Kevin M. ;

Yaspan, Brian L. ;

Wiklund, Fredrik ;

Stattin, Par ;

Lindstrom, Sara ;

Adami, Hans-Olov ;

McDonnell, Shannon K. ;

Schaid, Daniel J. ;

Cunningham, Julie M. ;

Wang, Liang ;

Cerhan, James R. ;

St Sauver, Jennifer L. ;

Isaacs, Sara D. ;

Wiley, Kathleen E. ;

Partin, Alan W. ;

Walsh, Patrick C. ;

Polo, Sonia ;

Ruiz-Echarri, Manuel ;

Navarrete, Sebastian ;

Fuertes, Fernando ;

Saez, Berta ;

Godino, Javier ;

Weijerman, Philip C. ;

Swinkels, Dorine W. ;

Aben, Katja K. .

NATURE GENETICS, 2008, 40 (03) :281-283

[9] Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Steinthorsdottir, Valgerdur ;

Bergthorsson, Jon T. ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Rafnar, Thorunn ;

Gudbjartsson, Daniel ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Blondal, Thorarinn ;

Stacey, Simon N. ;

Helgason, Agnar ;

Gunnarsdottir, Steinunn ;

Olafsdottir, Adalheidur ;

Kristinsson, Kari T. ;

Birgisdottir, Birgitta ;

Ghosh, Shyamali ;

Thorlacius, Steinunn ;

Magnusdottir, Dana ;

Stefansdottir, Gerdur ;

Kristjansson, Kristleifur ;

Bagger, Yu ;

Wilensky, Robert L. ;

Reilly, Muredach P. ;

Morris, Andrew D. ;

Kimber, Charlotte H. ;

Adeyemo, Adebowale ;

Chen, Yuanxiu ;

Zhou, Jie ;

So, Wing-Yee ;

Tong, Peter C. Y. ;

Ng, Maggie C. Y. ;

Hansen, Torben ;

Andersen, Gitte ;

Borch-Johnsen, Knut ;

Jorgensen, Torben ;

Tres, Alejandro ;

Fuertes, Fernando ;

Ruiz-Echarri, Manuel ;

Asin, Laura ;

Saez, Berta ;

van Boven, Erica ;

Klaver, Siem ;

Swinkels, Dorine W. ;

Aben, Katja K. ;

Graif, Theresa .

NATURE GENETICS, 2007, 39 (08) :977-983

[10] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

Isaacs, William B. ;

Catalona, William J. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine .

NATURE GENETICS, 2007, 39 (05) :631-637

← 1 2 3 →