Synthesis of Pyrano[3,2-c]pyrazol-7(1H)-one Derivatives by Tandem Cyclization of 2-Diazo-3,5-dioxo-6-ynoates (Ynones)

被引：21

作者：

Deng, Guisheng ^{[1
]}

Wang, Feng

Lu, Shengle

Cheng, Bo

机构：

[1] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ China, Changsha 410081, Hunan, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 19期

基金：

中国国家自然科学基金;

关键词：

1,3-DIPOLAR CYCLOADDITION; IDENTIFICATION; INHIBITORS; PYRANONE; POTENT; ACID;

D O I：

10.1021/acs.orglett.5b02369

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The construct of the core of pyrano[3,2-c]pyrazol-7(1H)-one derivatives is realized. The key step includes a tandem cyclization, namely, a metal-free cascade 6-pi electrocyclic ring closure-Michael reaction of 2-diazo-3,5-dioxo-6-ynoates (ynones). The cascade reaction cleanly generated the desired products in excellent yields under mild conditions.

引用

页码：4651 / 4653

页数：3

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