Natriuretic peptides in aortic stenosis

被引：4
作者：
Torres-Ramalho, Paulo [2 ,3 ]
Araujo, Jose Paulo [2 ,3 ]
Bettencourt, Paulo [2 ,3 ]
Moura, Luis M. [1 ,2 ]
机构：
[1] Hosp Pedro Hispano, Serv Cardiol, Matosinhos, Portugal
[2] Univ Porto, Fac Med, P-4100 Oporto, Portugal
[3] Hosp Sao Joao, Med Interna Serv, Oporto, Portugal
来源：
REVISTA PORTUGUESA DE CARDIOLOGIA | 2012年 / 31卷 / 10期
关键词：
Aortic stenosis; Natriuretic peptides; BNP; NT-proBNP; VALVE-REPLACEMENT; PLASMA-LEVELS; HEART-FAILURE; WALL STRESS; BRAIN; TRANSCATHETER; IMPLANTATION; SURVIVAL; EXERCISE; PREDICTORS;
D O I：
10.1016/j.repc.2012.07.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries. Diagnosis, risk stratification and monitoring are usually based on clinical and echo-cardiographic parameters. Complementary methods are needed to improve management and outcome, particularly in patients with severe asymptomatic AS, whose management remains controversial. Natriuretic peptides (NPs) have established value as biomarkers in heart failure, coronary heart disease and pulmonary hypertension. This review discusses the usefulness and prognostic value of natriuretic peptides in AS. B-type natriuretic peptide (BNP) and its prohormone (NT-proBNP) correlate with disease severity, development of symptoms and prognosis, but before they can be routinely used in clinical practice, additional prospective studies are needed. (C) 2011 Sociedade Portuguesa de Cardiologia Published by Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：655 / 660
页数：6
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