Age-Disparate Partnerships and Risk of HIV-1 Acquisition Among South African Women Participating in the VOICE Trial

被引：28

作者：

Balkus, Jennifer E. ^{[1
,2
]}

Nair, Gonasagrie ^{[3
]}

Montgomery, Elizabeth T. ^{[4
]}

Mishra, Anu ^{[5
]}

Palanee-Phillips, Thesla ^{[6
]}

Ramjee, Gita ^{[7
]}

Panchia, Ravindre ^{[8
]}

Selepe, Pearl ^{[9
]}

Richardson, Barbra A. ^{[1
,5
]}

Chirenje, Zvavahera M. ^{[10
]}

Marrazzo, Jeanne M. ^{[11
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

[2] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[3] Univ KwaZulu Natal, CAPRISA, Durban, South Africa

[4] RTI Int, San Francisco, CA USA

[5] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[6] Univ Witwatersrand, Johannesburg, South Africa

[7] South African Med Res Council, Durban, South Africa

[8] Chris Hani Baragwanath Hosp, Perinatal HIV Res Unit, Johannesburg, South Africa

[9] Aurum Inst, Klerksdorp, South Africa

[10] UZ UCSF, Harare, Zimbabwe

[11] Univ Washington, Dept Med, Seattle, WA USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2015年 / 70卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HIV-1 in women; age-disparate relationships; male partner; South Africa; sexual behavior; ANTIRETROVIRAL THERAPY; ADOLESCENT GIRLS; INFECTION; PATTERNS; SEX;

D O I：

10.1097/QAI.0000000000000715

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A recent analysis from South Africa reported no association between age-disparate relationships and HIV-1 acquisition. We assessed the association between male partner age and HIV-1 acquisition among South African women participating in the VOICE trial. Of 4077 women enrolled, 3789 had complete data; 26% and 5% reported having a partner >5 and >10 years older at enrollment, respectively. Reporting a partner >5 years older (hazard ratio = 1.00; 95% confidence interval: 0.74 to 1.35) or >10 older (hazard ratio = 0.92; 95% confidence interval: 0.49 to 1.74) was not associated with HIV-1 acquisition. These data corroborate recent reports and may suggest a shift in local epidemiology of heterosexual HIV-1 transmission.

引用

页码：212 / 217

页数：6

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