Hereditary diffuse gastric cancer - An overview

被引：11
作者：
Gurzu, Simona [1 ]
Jung, Ioan [1 ]
Orlowska, Janina [2 ,3 ]
Sugimura, Haruhiko [4 ]
Kadar, Zoltan [1 ,5 ]
Turdean, Sabin [1 ]
Bara, Tivadar, Jr. [6 ]
机构：
[1] Univ Med & Pharm Tirgu Mures, Dept Pathol, Targu Mures, Romania
[2] Maria Sklodowska Curie Mem Canc Ctr, Dept Pathol, Warsaw, Poland
[3] Inst Oncol, Warsaw, Poland
[4] Hamamatsu Univ Sch Med, Dept Tumor Pathol, Hamamatsu, Shizuoka 4313192, Japan
[5] Univ Med & Pharm Tirgu Mures, Dept Oncol, Targu Mures, Romania
[6] Univ Med & Pharm Tirgu Mures, Dept Surg, Targu Mures, Romania
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2015年 / 211卷 / 09期
关键词：
Hereditary gastric cancer; Adductomics; Geographic distribution; Ethnic difference; E-CADHERIN; GERMLINE MUTATIONS; STOMACH; FAMILY; RISK; CDH1; SURVEILLANCE; GASTRECTOMY; GUIDELINES; CARCINOMA;
D O I：
10.1016/j.prp.2015.06.003
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The incidence of gastric cancer varies by up to ten fold throughout the world, and the geographic distribution of hereditary cases is not well explored. Familial clustering is seen in 10% of cases, and approximately 3% of all gastric cancers develop due to hereditary diffuse gastric cancer (HDGC). In this review, the characteristics of HDGC are presented according to molecular particularities, geographic distribution, and other parameters. Based on our experience and the data from the literature, we discuss the possibility of applying a mutation signature (spectrum) study and adductomic approaches to a comparative carcinogenesis of HDGC. We also provide a comprehensive, up-to-date review of genetic counseling and criteria for screening and surveillance of eligible families. (C) 2015 Elsevier GmbH. All rights reserved.
引用
收藏
页码：629 / 632
页数：4
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