Statistics of DNA Capture by a Solid-State Nanopore

被引：83

作者：

Mihovilovic, Mirna ^{[1
]}

Hagerty, Nicholas ^{[1
]}

Stein, Derek ^{[1
]}

机构：

[1] Brown Univ, Dept Phys, Providence, RI 02912 USA

来源：

PHYSICAL REVIEW LETTERS | 2013年 / 110卷 / 02期

基金：

美国国家科学基金会;

关键词：

MOLECULES; TRANSLOCATION; TOPOLOGY; LENGTH;

D O I：

10.1103/PhysRevLett.110.028102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

A solid-state nanopore can electrophoretically capture a DNA molecule and pull it through in a folded configuration. The resulting ionic current signal indicates where along its length the DNA was captured. A statistical study using an 8-nm-wide nanopore reveals a strong bias favoring the capture of molecules near their ends. A theoretical model shows that bias to be a consequence of configurational entropy rather than a search by the polymer for an energetically favorable configuration. We also quantified the fluctuations and length dependence of the speed of simultaneously translocating polymer segments from our study of folded DNA configurations. DOI: 10.1103/PhysRevLett.110.028102

引用

页数：5

共 19 条

[1] SOME TESTS OF SCALING THEORY FOR A SELF-AVOIDING WALK ATTACHED TO A SURFACE [J].