Curbing cancer's sweet tooth: Is there a role for MnSOD in regulation of the Warburg effect?

被引：28

作者：

Holley, Aaron K. ^{[1
]}

Dhar, Sanjit Kumar ^{[1
]}

St Clair, Daret K. ^{[1
]}

机构：

[1] Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40536 USA

来源：

MITOCHONDRION | 2013年 / 13卷 / 03期

关键词：

Mitochondria; Manganese superoxide dismutase; Warburg effect; Cancer; Reactive oxygen species; MANGANESE-SUPEROXIDE-DISMUTASE; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; MITOCHONDRIAL-DNA MUTATIONS; MATRIX-METALLOPROTEINASE EXPRESSION; HYDROGEN-PEROXIDE PRODUCTION; DOXORUBICIN CHRONIC TOXICITY; INCREASES OXIDATIVE STRESS; OXYGEN SPECIES GENERATION; SQUAMOUS-CELL CARCINOMA; CYTOCHROME-C REDUCTASE;

D O I：

10.1016/j.mito.2012.07.104

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactive oxygen species (ROS), while vital for normal cellular function, can have harmful effects on cells, leading to the development of diseases such as cancer. The Warburg effect, the shift from oxidative phosphorylation to glycolysis, even in the presence of adequate oxygen, is an important metabolic change that confers many growth and survival advantages to cancer cells. Reactive oxygen species are important regulators of the Warburg effect The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. MnSOD is important in cancer development and progression. However, the significance of MnSOD in the regulation of the Warburg effect is just now being revealed, and it may significantly impact the treatment of cancer in the future. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：170 / 188

页数：19

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