Imaging blood flow inside highly scattering media using ultrasound modulated optical tomography

被引：21

作者：

Hussain, Altaf ^{[1
]}

Steenbergen, Wiendelt ^{[1
]}

Vellekoop, Ivo M. ^{[1
]}

机构：

[1] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Biomed Photon Imaging Grp, Box 217, NL-7500 AE Enschede, Netherlands

来源：

JOURNAL OF BIOPHOTONICS | 2018年 / 11卷 / 01期

基金：

欧洲研究理事会;

关键词：

medical and biological imaging; imaging through turbid media; acousto-optics; laser Doppler velocimetry; TAGGED PHOTONS; LASER SPECKLE; VELOCITY; LIGHT; SIGNALS;

D O I：

10.1002/jbio.201700013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the use of ultrasound modulated optical tomography (UOT) with heterodyne parallel detection to locally sense and image blood flow deep inside a highly scattering medium. We demonstrate that the UOT signal is sensitive to the speed of the blood flow in the ultrasound focus and present an analytical model that relates UOT signals to the optical properties (i.e. scattering coefficient, anisotropy, absorption, and flow speed) of the blood and the background medium. We found an excellent agreement between the experimental data and the analytical model. By varying the integration time of the camera in our setup, we were able to spatially resolve blood flow in a scattering medium with a lateral resolution of 1.5 mm. [GRAPHICS] .

引用

页数：10

共 36 条

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