cGAS-STING, an important pathway in cancer immunotherapy

被引：431

作者：

Jiang, Minlin ^{[1
,2
]}

Chen, Peixin ^{[1
,2
]}

Wang, Lei ^{[1
]}

Li, Wei ^{[1
]}

Chen, Bin ^{[1
]}

Liu, Yu ^{[1
,2
]}

Wang, Hao ^{[1
,2
]}

Zhao, Sha ^{[1
]}

Ye, Lingyun ^{[1
]}

He, Yayi ^{[1
]}

Zhou, Caicun ^{[1
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Canc Inst,Dept Med Oncol, 507 Zhengmin Rd, Shanghai 200433, Peoples R China

[2] Tongji Univ, 1239 Siping Rd, Shanghai 200433, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2020年 / 13卷 / 01期

基金：

中国国家自然科学基金;

关键词：

cGAS-STING; Cancer; Combined therapy; Immunotherapy; STING pathway; TUMOR MICROENVIRONMENT; I INTERFERON; CYCLIC DINUCLEOTIDE; DENDRITIC CELLS; DNA SENSOR; ACTIVATION; INNATE; INFLAMMATION; EXPRESSION; METASTASIS;

D O I：

10.1186/s13045-020-00916-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is an important novel role in the immune system. Multiple STING agonists were developed for cancer therapy study with great results achieved in pre-clinical work. Recent progress in the mechanical understanding of STING pathway in IFN production and T cell priming, indicates its promising role for cancer immunotherapy. STING agonists co-administrated with other cancer immunotherapies, including cancer vaccines, immune checkpoint inhibitors such as anti-programmed death 1 and cytotoxic T lymphocyte-associated antigen 4 antibodies, and adoptive T cell transfer therapies, would hold a promise of treating medium and advanced cancers. Despite the applications of STING agonists in cancer immunotherapy, lots of obstacles remain for further study. In this review, we mainly examine the biological characters, current applications, challenges, and future directions of cGAS-STING in cancer immunotherapy.

引用

页数：11

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