PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

被引：635
作者：
Marte, BM
Downward, J
机构：
[1] Imperial Cancer Research Fund, London, WC2A 3PX
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 09期
关键词：
D O I：
10.1016/S0968-0004(97)01097-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
PKB/Akt is a serine/threonine kinase that contains a pleckstrin-homology (PH) domain and is activated in response to growth-factor treatment of cells by a mechanism involving phosphoinositide 3-OH kinase. PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, perhaps explaining its discovery as a retroviral oncogene and its amplification in many human tumours.
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页码：355 / 358
页数：4
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