Early Postnatal IGF-1 and IGFBP-1 Blood Levels in Extremely Preterm Infants: Relationships with Indicators of Placental Insufficiency and with Systemic Inflammation

被引：12

作者：

Leviton, Alan ^{[1
,11
]}

Allred, Elizabeth N. ^{[1
,11
]}

Fichorova, Raina N. ^{[2
]}

VanderVeen, Deborah K. ^{[3
]}

O'Shea, T. Michael ^{[4
,16
]}

Kuban, Karl ^{[5
]}

Dammann, Olaf ^{[6
,7
]}

Shah, Bhavesh ^{[8
]}

Christianson, Karen ^{[8
]}

Martin, Camilia R. ^{[9
]}

Hallisey, Colleen ^{[9
]}

Hurley, Caitlin ^{[9
]}

Creixell, Miren ^{[9
]}

Van Marter, Linda J. ^{[10
]}

Lee, Kathleen ^{[11
]}

McGovern, Anne ^{[11
]}

Gambardella, Jill ^{[11
]}

Ursprung, Susan ^{[11
]}

Blomquist, Ruth ^{[11
]}

Insoft, Robert ^{[12
]}

Wilson, Jennifer G. ^{[12
]}

Pimental, Maureen ^{[12
]}

Cole, Cynthia ^{[13
]}

Fiascone, John ^{[13
]}

Madden, Janet ^{[13
]}

Nylen, Ellen ^{[13
]}

Furey, Anne ^{[13
]}

Bednarek, Francis ^{[14
]}

Naples, Mary ^{[14
]}

Powers, Beth ^{[14
]}

Ehrenkranz, Richard ^{[15
]}

Williams, Joanne ^{[15
]}

Romano, Elaine ^{[15
]}

Gordon, Debbie ^{[16
]}

Harold, Teresa ^{[16
]}

Hounsell, Gail ^{[16
]}

Hiatt, Debbie ^{[16
]}

Engelke, Stephen ^{[17
]}

Moseley, Sherry ^{[17
]}

Pare, Linda ^{[17
]}

Smart, Donna ^{[17
]}

Wilson, Joan ^{[17
]}

Bose, Carl ^{[18
]}

Bose, Gennie ^{[18
]}

Wereszczak, Janice ^{[18
]}

Portenga, Mariel ^{[19
]}

Sutton, Dinah ^{[19
]}

Karna, Padmani ^{[20
]}

Solomon, Carolyn ^{[20
]}

Schreiber, Michael D. ^{[21
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Obstet Gynecol & Reprod Biol, Boston, MA USA

[3] Harvard Med Sch, Boston Childrens Hosp, Dept Ophthalmol, Boston, MA 02115 USA

[4] Univ N Carolina, Dept Pediat, Chapel Hill, NC 27515 USA

[5] Boston Univ, Boston Med Ctr, Dept Pediat, Div Neurol, Boston, MA 02215 USA

[6] Tufts Univ, Sch Med, Dept Publ Hlth & Community Med, Boston, MA 02111 USA

[7] Hannover Med Sch, Perinatal Neuropidemiol Unit, Hannover, Germany

[8] Baystate Med Ctr, Springfield, MA USA

[9] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[10] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[11] Childrens Hosp, 300 Longwood Ave, Boston, MA 02115 USA

[12] Massachusetts Gen Hosp, Boston, MA 02114 USA

[13] Tufts Univ New England Med Ctr, 750 Washington St, Boston, MA 02111 USA

[14] U Mass Mem Hlth Ctr, Worcester, MA USA

[15] Yale New Haven Med Ctr, 20 York St, New Haven, CT 06504 USA

[16] Forsyth Hosp, Baptist Med Ctr, Winston Salem, NC USA

[17] Univ Hlth Syst Eastern Carolina, Greenville, NC USA

[18] North Carolina Childrens Hosp, Chapel Hill, NC USA

[19] DeVos Childrens Hosp, Grand Rapids, MI USA

[20] Sparrow Hosp, Lansing, MI USA

[21] Univ Chicago Hosp, Chicago, IL 60637 USA

[22] William Beaumont Hosp, Royal Oak, MI 48072 USA

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 2019年 / 36卷 / 14期

关键词：

IGF-1; neurotrophic factors; cytokines; inflammation; infant; blood; angiogenic; placenta insufficiency; fetal growth restriction; preeclampsia; GROWTH-FACTOR-I; 28TH WEEK; BRONCHOPULMONARY DYSPLASIA; PREGNANCY DISORDERS; CHILDREN BORN; INSULIN; RETINOPATHY; PREMATURITY; FETAL; PROTEINS;

D O I：

10.1055/s-0038-1677472

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective To evaluate to what extent indicators of placenta insufficiency are associated with low concentrations of insulin-like growth factor 1 (IGF-1) and IGF-1-binding protein-1 (IGFBP-1) in neonatal blood, and to what extent the concentrations of these growth factors are associated with concentrations of proteins with inflammatory, neurotrophic, or angiogenic properties. Study Design Using multiplex immunoassays, we measured the concentrations of IGF-1 and IGFBP-1, as well as 25 other proteins in blood spots collected weekly from >= 880 infants born before the 28th week of gestation, and sought correlates of concentrations in the top and bottom quartiles for gestational age and day the specimen was collected. Results Medically indicated delivery and severe fetal growth restriction (sFGR) were associated with low concentrations of IGF-1 on the first postnatal day and with high concentrations of IGFBP-1 on almost all days. Elevated concentrations of IGF-1 and IGFBP-1 were accompanied by elevated concentrations of many other proteins with inflammatory, neurotrophic, or angiogenic properties. Conclusion Disorders associated with impaired placenta implantation and sFGR appear to account for a relative paucity of IGF-1 on the first postnatal day. Elevated concentrations of IGF-1 and especially IGFBP-1 were associated with same-day elevated concentrations of inflammatory, neurotrophic, and angiogenic proteins.

引用

页码：1442 / 1452

页数：11

共 82 条

[71] Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children
Riikonen, Raili
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (10)
[72] Oxidation of placental insulin and insulin-like growth factor receptors in mothers with diabetes mellitus or preeclampsia complicated with intrauterine growth restriction
Robajac, D.
Masnikosa, R.
Mikovic, Z.
Mandie, V.
Nedic, O.
[J]. FREE RADICAL RESEARCH, 2015, 49 (08) : 984 - 989
[73] Rothman K J, 1990, Epidemiology, V1, P43, DOI 10.1097/00001648-199001000-00010
[74] Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth
Sferruzzi-Perri, Amanda N.
Sandovici, Ionel
Constancia, Miguel
Fowden, Abigail L.
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 2017, 595 (15): : 5057 - 5093
[75] Direct regulation of IGF-binding protein 1 promoter by interleukin-1β via an insulin- and FoxO-1-independent mechanism
Shi, L.
Banerjee, D.
Dobierzewska, A.
Sathishkumar, S.
Karakashian, A. A.
Giltiay, N. V.
Nikolova-Karakashian, M. N.
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2016, 310 (08): : E612 - E623
[76] The Biology of Retinopathy of Prematurity How Knowledge of Pathogenesis Guides Treatment
Smith, Lois E.
Hard, Anna-Lena
Hellstrom, Ann
[J]. CLINICS IN PERINATOLOGY, 2013, 40 (02) : 201 - +
[77] Tian F, 2017, EUR REV MED PHARMACO, V21, P4711
[78] Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
Weber, Michael
Hellmann, Ines
Stadler, Michael B.
Ramos, Liliana
Paabo, Svante
Rebhan, Michael
Schubeler, Dirk
[J]. NATURE GENETICS, 2007, 39 (04) : 457 - 466
[79] A genomic storm in critically injured humans
Xiao, Wenzhong
Mindrinos, Michael N.
Seok, Junhee
Cuschieri, Joseph
Cuenca, Alex G.
Gao, Hong
Hayden, Douglas L.
Hennessy, Laura
Moore, Ernest E.
Minei, Joseph P.
Bankey, Paul E.
Johnson, Jeffrey L.
Sperry, Jason
Nathens, Avery B.
Billiar, Timothy R.
West, Michael A.
Brownstein, Bernard H.
Mason, Philip H.
Baker, Henry V.
Finnerty, Celeste C.
Jeschke, Marc G.
Lopez, M. Cecilia
Klein, Matthew B.
Gamelli, Richard L.
Gibran, Nicole S.
Arnoldo, Brett
Xu, Weihong
Zhang, Yuping
Calvano, Steven E.
McDonald-Smith, Grace P.
Schoenfeld, David A.
Storey, John D.
Cobb, J. Perren
Warren, H. Shaw
Moldawer, Lyle L.
Herndon, David N.
Lowry, Stephen F.
Maier, Ronald V.
Davis, Ronald W.
Tompkins, Ronald G.
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (13) : 2581 - 2590
[80] NEW BIRTH-WEIGHT AND HEAD CIRCUMFERENCE CENTILES FOR GESTATIONAL AGES 24 TO 42 WEEKS
YUDKIN, PL
ABOUALFA, M
EYRE, JA
REDMAN, CWG
WILKINSON, AR
[J]. EARLY HUMAN DEVELOPMENT, 1987, 15 (01) : 45 - 52

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