A simple approach to pyrazol-3-ones via diazenes

被引：15

作者：

Burja, Bojan ^{[1
]}

Kocevar, Marijan ^{[1
]}

Polanc, Slovenko ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Chem & Chem Technol, SI-1000 Ljubljana, Slovenia

来源：

TETRAHEDRON | 2009年 / 65卷 / 42期

关键词：

Diazenes; Intramolecular amination; Pyrazol-3-ones; Mild hydrolysis; ELECTROPHILIC AMINATION; BIOLOGICAL EVALUATION; DERIVATIVES; REACTIVITY;

D O I：

10.1016/j.tet.2009.08.047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient entry into pyrazol-3-ones is described starting from propenoic acids that were first transformed into the corresponding hydrazides. Oxidation of the hydrazides gave the diazenes and the latter cyclized to pyrazol-3-ones on treatment with ZrCl4. The methoxycarbonyl protection of the N-1 of the pyrazolone derivatives was easily removed under mild reaction conditions. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：8690 / 8696

页数：7

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