In Vitro Activity of Ceftazidime-Avibactam against Isolates in a Phase 3 Open-Label Clinical Trial for Complicated Intra-Abdominal and Urinary Tract Infections Caused by Ceftazidime-Nonsusceptible Gram-Negative Pathogens

被引：23
|
作者：
Stone, Gregory G. [1 ]
Bradford, Patricia A. [1 ]
Newell, Paul [2 ]
Wardman, Angela [2 ]
机构：
[1] AstraZeneca, Waltham, MA 02451 USA
[2] AstraZeneca, Alderley Pk, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 02期
关键词：
ceftazidime nonsusceptible; ceftazidime-avibactam; in vitro activity; BETA-LACTAMASE INHIBITOR; COMBINATION; NXL104;
D O I：
10.1128/AAC.01820-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro activity of ceftazidime-avibactam was evaluated against 341 Gram-negative isolates from 333 patients in a randomized, phase 3 clinical trial of patients with complicated urinary tract or intra-abdominal infections caused by ceftazidime-nonsusceptible pathogens (NCT01644643). Ceftazidime-avibactam MIC90 values against Enterobacteriaceae and Pseudomonas aeruginosa (including several class B or D enzyme producers that avibactam does not inhibit) were 1 and 64 mu g/ml, respectively. Overall, the ceftazidime-avibactam activity against ceftazidime-nonsusceptible isolates was comparable to the activity of ceftazidime-avibactam previously reported against ceftazidime-susceptible isolates.
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