Identification of genes that correlate clear cell renal cell carcinoma and obesity and exhibit potential prognostic value

被引:8
作者
Zhou, Jiale [1 ]
Yang, Zhaolin [1 ]
Wu, Xiaorong [1 ]
Zhang, Jin [1 ]
Zhai, Wei [1 ]
Chen, Yonghui [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Urol, 160 Pujian Rd, Shanghai 200127, Peoples R China
基金
中国国家自然科学基金;
关键词
Clear cell renal cell carcinoma (ccRCC); obesity; prognosis; biomarker; MONOAMINE-OXIDASE; CANCER; EXPRESSION; ASSOCIATION; ACTIVATION; MECHANISMS; LEPTIN; RISK; IGKC;
D O I
10.21037/tau-20-891
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
Background: Renal cell carcinoma (RCC) is a common urologic malignancy. Although the relationship between clear cell RCC (ccRCC) and obesity has been well-established by several large-scale retrospective studies, the molecular mechanisms and genetic characteristics behind this correlation remains unclear. In the current study, several bioinformatics tools were used to identify the key genes in ccRCC related to obesity. Methods: Microarray data comparing ccRCC with normal renal tissues in patients with and without obesity were downloaded from the GEO database for screening of differentially expressed genes (DEGs). The DEGs were verified with expression level and survival analysis using several online bioinformatics tools. Results: In the current study, the differential expression of five genes correlated with both ccRCC and obesity; IGHA1 and IGKC as oncogenes, and MAOA, MUC20 and TRPM3 as tumor suppressor genes. These genes were verified by comparing the relationship between the expression levels and survival outcomes from open-source data in The Cancer Genome Atlas (TCGA) dataset. Conclusions: In conclusion, the five genes differentially expressed in ccRCC and obesity are related to disease progression and prognosis, and therefore could provide prognostic value for patients with ccRCC.
引用
收藏
页码:680 / 691
页数:12
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