The chemistry of nucleoside and dinucleotide inhibitors of inosine monophosphate dehydrogenase (IMPDH)

被引：2
|
作者：
Pankiewicz, KW [1 ]
Goldstein, BM [1 ]
机构：
[1] Pharmasset Inc, Atlanta, GA 30084 USA
来源：
RECENT ADVANCES IN NUCLEOSIDES: CHEMISTRY AND CHEMOTHERAPY | 2002年
关键词：
D O I：
10.1016/B978-044450951-2/50004-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：71 / 90
页数：20
相关论文
共 50 条
  • [41] Triazole Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase
    Maurya, Sushil K.
    Gollapalli, Deviprasad R.
    Kirubakaran, Shivapriya
    Zhang, Minjia
    Johnson, Corey R.
    Benjamin, Nicole N.
    Hedstrom, Lizbeth
    Cuny, Gregory D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (15) : 4623 - 4630
  • [42] Inosine 5′-monophosphate dehydrogenase inhibitors for the treatment of autoimmune diseases
    Ratcliffe, Andrew J.
    CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2006, 9 (05) : 595 - 605
  • [43] The structure of inosine 5′-monophosphate dehydrogenase and the design of novel inhibitors
    Sintchak, MD
    Nimmesgern, E
    IMMUNOPHARMACOLOGY, 2000, 47 (2-3): : 163 - 184
  • [44] Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase
    Iwanowicz, EJ
    Watterson, SH
    Liu, CJ
    Gu, HH
    Mitt, T
    Leftheris, K
    Barrish, JC
    Fleener, CA
    Rouleau, K
    Sherbina, NZ
    Hollenbaugh, DL
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (20) : 2931 - 2934
  • [45] Virtual and experimental high-throughput screening (HTS) in search of novel inosine 5′-monophosphate dehydrogenase II (IMPDH II) inhibitors
    Torsten Dunkern
    Arati Prabhu
    Prashant S. Kharkar
    Heike Goebel
    Edith Rolser
    Waltraud Burckhard-Boer
    Premkumar Arumugam
    Mahindra T. Makhija
    Journal of Computer-Aided Molecular Design, 2012, 26 : 1277 - 1292
  • [46] Virtual and experimental high-throughput screening (HTS) in search of novel inosine 5′-monophosphate dehydrogenase II (IMPDH II) inhibitors
    Dunkern, Torsten
    Prabhu, Arati
    Kharkar, Prashant S.
    Goebel, Heike
    Rolser, Edith
    Burckhard-Boer, Waltraud
    Arumugam, Premkumar
    Makhija, Mahindra T.
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2012, 26 (11) : 1277 - 1292
  • [47] Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase
    Rejman, Dominik
    Olesiak, Magda
    Chen, Liqiang
    Patterson, Steven E.
    Wilson, Daniel
    Jayaram, Hiramagalur N.
    Hedstrom, Lizbeth
    Pankiewicz, Krzysztof W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (16) : 5018 - 5022
  • [48] Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: Inhibition of inosine monophosphate dehydrogenase
    Chen, Liqiang
    Petrelli, Riccardo
    Olesiak, Magdalena
    Wilson, Daniel J.
    Labello, Nicholas P.
    Pankiewicz, Krzysztof W.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (15) : 7462 - 7469
  • [49] Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor
    Chen, Liqiang
    Gao, Guangyao
    Bonnac, Laurent
    Wilson, Daniel J.
    Bennett, Eric M.
    Jayaram, Hiremagalur N.
    Pankiewicz, Krzysztof W.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (11) : 3152 - 3155
  • [50] Monitoring of mycophenolic acid therapy in renal transplant patients by inosine-monophosphate-dehydrogenase (IMPDH) activity
    Sommerer, Claudia
    Mueller-Krebs, Sandra
    Schaier, Matthias
    Glander, Petra
    Schwemaer, Vedat
    Zeier, Martin
    AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 : 586 - 586
12345