Metallatranes and hydrometallatranes: their immunotropic and antitumor properties

被引：11

作者：

Adamovich, S. N. ^{[1
]}

Oborina, E. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Branch, AE Favorsky Irkutsk Inst Chem, 1 Ul Favorskogo, Irkutsk 664033, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2019年 / 68卷 / 09期

关键词：

atranes; metallatranes; hydrometallatranes; immunostimulants; immunosuppressants; cytotoxic activity; COMPLEX; SALTS;

D O I：

10.1007/s11172-019-2616-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of biologically active metallatranes and hydrometallatranes was synthesized via the reaction of biogenic triethanolamine with salts or oxides of the essential metals; their toxicity was determined, and the immunotropic and cytotoxic properties were evaluated. Compounds causing immunostimulatory, immunosuppressive, and also competing effects on the immune response were revealed. A pronounced immunosuppressant, 1-oxovanadatran, exhibits a high and selective cytotoxic effect, inhibiting the growth of B16 melanoma cells by 39-80%, but does not affect the tumor cells of L1210 lymphocytic leukemia, P815 mastocytoma, and Lewis lung carcinoma.

引用

页码：1723 / 1728

页数：6

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