Surface engineering of poly(D,L-lactic acid) by entrapment of soluble eggshell membrane protein

被引:19
作者
Lu, Jian-Wei [1 ]
Li, Qiang [1 ]
Qi, Qing-Lei [1 ]
Guo, Zhao-Xia [1 ]
Yu, Jian [1 ]
机构
[1] Tsinghua Univ, Dept Chem Engn, Inst Polymer Sci & Engn, Sch Mat Sci & Engn, Beijing 100084, Peoples R China
关键词
poly(D; L-lactic acid); eggshell membrane; entrapment; surface; modification; POLY(DL-LACTIC ACID); POLY(LACTIC ACID); COLLAGEN; CHONDROGENESIS; DERIVATIVES; PROMOTION; FILM;
D O I
10.1002/jbm.a.32304
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Soluble eggshell membrane protein (SEP) is used to engineer poly(D,L-lactic acid) (PDL-LA) membrane surface by a physical entrapment method to enhance cytocompatibility. Attenuated total reflection Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and contact angle measurements are used to characterize SEP-modified PDL-LA membrane surface and confirm the formation of an even and stable layer of SEP on PDL-LA membrane surface. NIH3T3 cell lines are used as model cells to evaluate cytocompatibility of the SEP-modified PDL-LA membrane, which is much better than that of virgin PDL-LA membrane. The enhanced cytocompatibility facilitates potential application in tissue engineering. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91A: 701-707,2009
引用
收藏
页码:701 / 707
页数:7
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