The INK4α/ARF locus in murine tumorigenesis

被引：89

作者：

Serrano, M ^{[1
]}

机构：

[1] Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

来源：

CARCINOGENESIS | 2000年 / 21卷 / 05期

关键词：

D O I：

10.1093/carcin/21.5.865

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The INK4a/ARF locus is regarded as one of the most important anti-tumoral defenses that mammalian organisms possess. The characterization of its two gene products, p16(INK4a) and p19(ARF), has provided a great insight on the functioning of the tumor suppressors Ph and p53, respectively. Present evidence indicates that the INK4a/ARF locus is transcriptionally activated by oncogenic stresses, resulting in cell-cycle arrest or apoptosis, Here, I review the evidence accumulated on the involvement of the INK4a/ ARF locus in murine turnorigenesis. Also, I summarize the phenotype of the different transgenic mouse models based on the inactivation of the INK4a/ARF locus.

引用

页码：865 / 869

页数：5

共 64 条

[1] p16 gene overexpression in mouse bladder carcinomas [J].

Asamoto, M ;

Hori, T ;

Baba-Toriyama, H ;

Sano, M ;

Takahashi, S ;

Tsuda, H ;

Shirai, T .

CANCER LETTERS, 1998, 127 (1-2) :9-13

[2] Alterations in cell cycle regulation in mouse skin tumors [J].

Balasubramanian, S ;

Ahmad, N ;

Jeedigunta, S ;

Mukhtar, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 243 (03) :744-748

[3] p14ARF links the tumour suppressors RB and p53 [J].

Bates, S ;

Phillips, AC ;

Clark, PA ;

Stott, F ;

Peters, G ;

Ludwig, RL ;

Vousden, KH .

NATURE, 1998, 395 (6698) :124-125

[4] Deletion and differential expression of p16(INK4a) in mouse lung tumors [J].

Belinsky, SA ;

Swafford, DS ;

Middleton, SK ;

Kennedy, CH ;

Tesfaigzi, J .

CARCINOGENESIS, 1997, 18 (01) :115-120

[5] Essential role for oncogenic Ras in tumour maintenance [J].

Chin, L ;

Tam, A ;

Pomerantz, J ;

Wong, M ;

Holash, J ;

Bardeesy, N ;

Shen, Q ;

O'Hagan, R ;

Pantginis, J ;

Zhou, H ;

Horner, JW ;

Cordon-Cardo, C ;

Yancopoulos, GD ;

DePinho, RA .

NATURE, 1999, 400 (6743) :468-472

[6]

CHIN L, 1998, GENE DEV, V12, P2822

[7] Allelic loss and promoter hypermethylation of the p15INK4b gene features in mouse radiation-induced lymphoid -: but not myeloid -: leukaemias [J].

Cleary, HJ ;

Boulton, E ;

Plumb, M .

LEUKEMIA, 1999, 13 (12) :2049-2052

[8] E1A signaling to p53 involves the p19ARF tumor suppressor [J].

de Stanchina, E ;

McCurrach, ME ;

Zindy, F ;

Shieh, SY ;

Ferbeyre, G ;

Samuelson, AV ;

Prives, C ;

Roussel, MF ;

Sherr, CJ ;

Lowe, SW .

GENES & DEVELOPMENT, 1998, 12 (15) :2434-2442

[9]

DURO D, 1995, ONCOGENE, V11, P21

[10] Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis [J].

Eischen, CM ;

Weber, JD ;

Roussel, MF ;

Sherr, CJ ;

Cleveland, JL .

GENES & DEVELOPMENT, 1999, 13 (20) :2658-2669

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