Concise Review: Emerging Drugs Targeting Epithelial Cancer Stem-Like Cells

被引：31

作者：

Ahmed, Mehreen ^{[1
]}

Chaudhari, Kritika ^{[4
]}

Babaei-Jadidi, Roya ^{[1
,2
]}

Dekker, Lodewijk V. ^{[3
]}

Nateri, Abdolrahman Shams ^{[1
]}

机构：

[1] Univ Nottingham, Ctr Biomol Sci, Sch Pharm, Canc Genet & Stem Cell Grp, Nottingham, England

[2] Univ Nottingham, Ctr Biomol Sci, Sch Med,Canc Biol, Tumor & Vasc Biol Labs,Div Canc & Stem Cells, Nottingham, England

[3] Univ Nottingham, Ctr Biomol Sci, Sch Pharm, Div Med Chem & Struct Biol, Nottingham, England

[4] Biomed Insights Ltd, Nottingham, England

来源：

STEM CELLS | 2017年 / 35卷 / 04期

基金：

英国医学研究理事会;

关键词：

Cancer stem cells; Cell signaling; Differentiation; Self-renewal; Tissue-specific stem cells; Signal transduction; Targeted therapy; Drug targets; NEGATIVE BREAST-CANCER; TUMOR-INITIATING CELLS; SMALL-MOLECULE INHIBITOR; LUNG-CANCER; COLORECTAL-CANCER; IN-VITRO; MESENCHYMAL TRANSITION; SIDE POPULATION; SELF-RENEWAL; RESISTANCE;

D O I：

10.1002/stem.2579

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Increasing evidence suggests that cancer cell populations contain a small proportion of cells that display stem-like cell properties and which may be responsible for overall tumor maintenance. These cancer stem-like cells (CSCs) appear to have unique tumor-initiating ability and innate survival mechanisms that allow them to resist cancer therapies, consequently promoting relapses. Selective targeting of CSCs may provide therapeutic benefit and several recent reports have indicated this may be possible. In this article, we review drugs targeting CSCs, in selected epithelial cell-derived cancers.

引用

收藏

页码：839 / 850

页数：12

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