A flowcytometric study of CD4+ & CD19+ cell lymphopenia in patients with alopecia areata

被引：0

作者：

Sharma, VK ^{[1
]}

Agnihotri, N ^{[1
]}

Ganguly, NK ^{[1
]}

Vohra, H ^{[1
]}

机构：

[1] POSTGRAD INST MED EDUC & RES,DEPT EXPT MED & BIOTECHNOL,CHANDIGARH 160012,INDIA

来源：

INDIAN JOURNAL OF MEDICAL RESEARCH | 1996年 / 104卷

关键词：

activated lymphocytes; alopecia areata; B cells; CD4+ and CD8+ ratio; natural killer cells; T cell subsets;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Twenty five patients with alopecia areata and 20 healthy controls were studied by flowcytometry employing direct two colour immunofluorescence in erythrocyte lysed whole blood. A significant reduction was observed in helper/inducer (CD4+) lymphocytes (29.4+/-7.4 vs 39.45+/-8.0, P < 0.01) and B (CD 19+) lymphocytes (11.04+/-6.57 vs 15.0+/-5.05, P < 0.01) in comparison with healthy controls. Decrease in T-lymphocytes (CD3+) and suppressor/cytotoxic (CD8+) was not significant and activated (HLADR+) lymphocytes and natural killer cells (CD16+ and CD56+) were within normal limits. Our findings suggest a significant T helper (CD4+) and B (CD19+) cell lymphopenia in alopecia areata.

引用

页码：296 / 298

页数：3

共 21 条

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