Oral cancer and polymorphism of ethanol metabolising genes

被引：15

作者：

Marichalar-Mendia, Xabier ^{[1
]}

Rodriguez-Tojo, Maria J. ^{[1
]}

Acha-Sagredo, Amelia ^{[1
]}

Rey-Barja, Natalia ^{[1
]}

Aguirre-Urizar, Jose M. ^{[1
]}

机构：

[1] Univ Basque Country, Dept Stomatol, Fac Med & Odontol, EHU, Bizkaia 48940, Spain

来源：

ORAL ONCOLOGY | 2010年 / 46卷 / 01期

关键词：

Alcohol; ADH; ALDH; CYP2E1; Oral cancer; Polymorphism; SQUAMOUS-CELL CARCINOMA; GLUTATHIONE-S-TRANSFERASE; ALCOHOL-DEHYDROGENASE; 3; NECK-CANCER; ALDEHYDE DEHYDROGENASES; CYTOCHROME P-4502E1; POOLED ANALYSIS; ADH GENES; HEAD; RISK;

D O I：

10.1016/j.oraloncology.2009.09.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oral cancer is the sixth most common cancer worldwide and a major health problem in some parts of the world. Epidemiological studies have shown that habitual alcohol consumption could be a risk factor in oral carcinogenesis, although the true involvement of alcohol is unknown. Via alcohol dehydrogenase (ADH) and cytochrome P450 oxidase (CYP) alcohol is metabolized to acetaldehyde, a highly toxic compound, which plays an important role in carcinogenesis. Subsequently, and during the metabolizing process, acetaldehyde becomes acetate by acetaldehyde dehydrogenase (ALDH). Therefore, acetaldehyde levels are determined mainly by the action of ADH, CYP and ALDH. Recently, several studies have found that certain polymorphisms of genes encoding these enzymes confer a higher or lower metabolic activity and therefore different risk for certain malignancies such as oral cancer. In this review, we analyze the polymorphisms of alcohol metabolising enzymes in relation susceptibility to an oral cancer. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：9 / 13

页数：5

共 58 条

[11] Families of retinoid dehydrogenases regulating vitamin A function - Production of visual pigment and retinoic acid [J].

Duester, G .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (14) :4315-4324

[12] Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family [J].

Duester, G ;

Farrés, J ;

Felder, MR ;

Holmes, RS ;

Höög, JO ;

Parés, X ;

Plapp, BV ;

Yin, SJ ;

Jörnvall, H .

BIOCHEMICAL PHARMACOLOGY, 1999, 58 (03) :389-395

[13] EXPRESSION OF CYTOCHROME-P450 AND MICROSOMAL EPOXIDE HYDROLASE IN CERVICAL AND ORAL EPITHELIAL-CELLS IMMORTALIZED BY HUMAN PAPILLOMAVIRUS TYPE-16 E6/E7 GENES [J].

FARIN, FM ;

BIGLER, LG ;

ODA, D ;

MCDOUGALL, JK ;

OMIECINSKI, CJ .

CARCINOGENESIS, 1995, 16 (06) :1391-1401

[14] Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer [J].

Figaro Gattas, Gilka Jorge ;

Brasilino de Carvalho, Marcos ;

Salete Siraque, Maria ;

Curioni, Otavio A. ;

Kohler, Priscila ;

Eluf-Neto, Jose ;

Wunsch-Filho, Victor .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2006, 28 (09) :819-826

[15] CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma [J].

Gajecka, M ;

Rydzanicz, M ;

Jaskula-Sztul, R ;

Kujawski, M ;

Szyfter, W ;

Szyfter, K .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 574 (1-2) :112-123

[16] Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers [J].

Harty, LC ;

Caporaso, NE ;

Hayes, RB ;

Winn, DM ;

BravoOtero, E ;

Blot, WJ ;

Kleinman, DV ;

Brown, LM ;

Armenian, HK ;

Fraumeni, JF ;

Shields, PG .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (22) :1698-1705

[17] Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract [J].

Hashibe, M ;

Boffetta, P ;

Zaridze, D ;

Shangina, O ;

Szeszenia-Dabrowska, N ;

Mates, D ;

Janout, V ;

Fabiánova, E ;

Bencko, V ;

Moullan, N ;

Chabrier, A ;

Hung, RJ ;

Hall, J ;

Canzian, F ;

Brennan, P .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (04) :696-703

[18] Multiple ADH genes are associated with upper aerodigestive cancers [J].

Hashibe, Mia ;

Mckay, James D. ;

Curado, Maria Paula ;

Oliveira, Jose Carlos ;

Koifman, Sergio ;

Koifman, Rosalina ;

Zaridze, David ;

Shangina, Oxana ;

Wuensch-Filho, Victor ;

Eluf-Neto, Jose ;

Levi, Jose Eduardo ;

Matos, Elena ;

Lagiou, Pagona ;

Lagiou, Areti ;

Benhamou, Simone ;

Bouchardy, Christine ;

Szeszenia-Dabrowska, Neonilia ;

Menezes, Ana ;

Dall'Agnol, Marinel Mor ;

Merletti, Franco ;

Richiardi, Lorenzo ;

Fernandez, Leticia ;

Lence, Juan ;

Talamini, Renato ;

Barzan, Luigi ;

Mates, Dana ;

Mates, Ioan Nicolae ;

Kjaerheim, Kristina ;

Macfarlane, Gary J. ;

Macfarlane, Tatiana V. ;

Simonato, Lorenzo ;

Canova, Cristina ;

Holcatova, Ivana ;

Agudo, Antonio ;

Castellsague, Xavier ;

Lowry, Ray ;

Janout, Vladimir ;

Kollarova, Helena ;

Conway, David I. ;

McKinney, Patricia A. ;

Znaor, Ariana ;

Fabianova, Eleonora ;

Bencko, Vladimir ;

Lissowska, Jolanta ;

Chabrier, Amelie ;

Hung, Rayjean J. ;

Gaborieau, Valerie ;

Boffetta, Paolo ;

Brennan, Paul .

NATURE GENETICS, 2008, 40 (06) :707-709

[19] Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer:: Pooled analysis in the international head and neck cancer epidemiology consortium [J].

Hashibe, Mia ;

Brennan, Paul ;

Benhamou, Simone ;

Castellsague, Xavier ;

Chu Chen ;

Paula Curado, Maria ;

Dal Maso, Luigino ;

Dauct, Alexander W. ;

Fabianova, Eleonora ;

Wunsch-Filho, Victor ;

Franceschi, Silvia ;

Hayes, Richard B. ;

Herrero, Rolando ;

Koifman, Sergio ;

La Vecchia, Carlo ;

Lazarus, Philip ;

Levi, Fabio ;

Mates, Dana ;

Matos, Elena ;

Menezes, Ana ;

Muscat, Joshua ;

Eluf-Neto, Jose ;

Olshan, Andrew F. ;

Rudnai, Peter ;

Schwartz, Stephen M. ;

Smith, Elaine ;

Sturgis, Erich M. ;

Szeszenia-Dabrowska, Neonilia ;

Talamini, Renato ;

Wei, Qingyi ;

Winn, Deborah M. ;

Zaridze, David ;

Zatonski, Witold ;

Zhang, Zuo-Feng ;

Berthiller, Julien ;

Boffetta, Paolo .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (10) :777-789

[20] GENETIC POLYMORPHISMS IN THE 5'-FLANKING REGION CHANGE TRANSCRIPTIONAL REGULATION OF THE HUMAN CYTOCHROME P450IIE1 GENE [J].

HAYASHI, S ;

WATANABE, J ;

KAWAJIRI, K .

JOURNAL OF BIOCHEMISTRY, 1991, 110 (04) :559-565

← 1 2 3 4 5 6 →