EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRIMIDINES

被引：8

作者：

Khatri, Taslimahemad T. ^{[1
,2
]}

Shah, Viresh H. ^{[3
]}

机构：

[1] Lovely Profess Univ, Dept Chem, Phagwara 144411, India

[2] KSKV Kachchh Univ, Dept Chem, Bhuj 370001, India

[3] Saurashtra Univ, Dept Chem, Rajkot 360009, Gujarat, India

来源：

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2017年 / 62卷 / 01期

关键词：

Gewald reaction; thieno[2,3-d]pyrimidines; thieno[2,3-d]pyrimidin-2(1H)-ones; antimicrobial activity; BIOLOGICAL EVALUATION; DERIVATIVES; ANTAGONISTS; SERIES;

D O I：

10.4067/S0717-97072017000100010

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel 2-amino-3-cyanothiophenes (2a-2j) were synthesized using heterogeneous base (K2CO3) supported Gewald reaction. Cyclization of 2a-j with formamide and urea in conventional heating as well as microwave irradiation gave thieno[2,3-d]pyrimidines (3a-3j) and thieno[2,3-d]pyrimidin-2(1H)-ones(4a-4j) respectively. The reaction rates were faster and yields were higher in the microwave conditions. The structures of the compounds were confirmed with elemental analysis, mass spectral analysis, FTIR, H-1 NMR and C-13 NMR techniques. All the synthesized compounds were subjected to antimicrobial activity (MIC) in vitro by broth dilution method and exhibited a moderate antimicrobial activity.

引用

页码：3354 / 3358

页数：5

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