Simplified algorithm to facilitate communication of familial hypercholesterolaemia

被引:12
作者
Laufs, Ulrich [1 ]
Parhofer, Klaus G. [2 ]
机构
[1] Univ Klinikum Saarlandes, Klin Innere Med Kardiol Angiol & Internist Intens, D-66421 Homburg, Germany
[2] Klinikum Univ Munchen, Med Klin 2, Munich, Germany
关键词
DENSITY-LIPOPROTEIN CHOLESTEROL; SUBTILISIN/KEXIN TYPE 9; CORONARY-HEART-DISEASE; MONOCLONAL-ANTIBODY; CONTROLLED-TRIAL; AMG; 145; PCSK9;
D O I
10.1093/eurheartj/ehv441
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:3004 / 3006
页数:3
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  • [1] Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease A Mendelian Randomization Analysis
    Ference, Brian A.
    Yoo, Wonsuk
    Alesh, Issa
    Mahajan, Nitin
    Mirowska, Karolina K.
    Mewada, Abhishek
    Kahn, Joel
    Afonso, Luis
    Williams, Kim Allan, Sr.
    Flack, John M.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (25) : 2631 - 2639
  • [2] Genetic screening protocol for familial hypercholesterolemia which includes splicing defects gives an improved mutation detection rate
    Graham, CA
    McIlhatton, BP
    Kirk, CW
    Beattie, ED
    Lyttle, K
    Hart, P
    Neely, RDG
    Young, IS
    Nicholls, DP
    [J]. ATHEROSCLEROSIS, 2005, 182 (02) : 331 - 340
  • [3] A molecular genetic service for diagnosing individuals with familial hypercholesterolaemia (FH) in the United Kingdom
    Heath, KE
    Humphries, SE
    Middleton-Price, H
    Boxer, M
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2001, 9 (04) : 244 - 252
  • [4] Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    Jonathan, C
    Pertsemlidis, A
    Kotowski, IK
    Graham, R
    Christine, KG
    Garcia, CK
    Hobbs, HH
    [J]. NATURE GENETICS, 2005, 37 (02) : 161 - 165
  • [5] ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia
    Kastelein, John J. P.
    Ginsberg, Henry N.
    Langslet, Gisle
    Hovingh, G. Kees
    Ceska, Richard
    Dufour, Robert
    Blom, Dirk
    Civeira, Fernando
    Krempf, Michel
    Lorenzato, Christelle
    Zhao, Jian
    Pordy, Robert
    Baccara-Dinet, Marie T.
    Gipe, Daniel A.
    Geiger, Mary Jane
    Farnier, Michel
    [J]. EUROPEAN HEART JOURNAL, 2015, 36 (43) : 2996 - 3003
  • [6] Familial Hypercholesterolemia: Developments in Diagnosis and Treatment
    Klose, Gerald
    Laufs, Ulrich
    Maerz, Winfried
    Windler, Eberhard
    [J]. DEUTSCHES ARZTEBLATT INTERNATIONAL, 2014, 111 (31-32): : 523 - +
  • [7] Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease
    Nordestgaard, Borge G.
    Chapman, M. John
    Humphries, Steve E.
    Ginsberg, Henry N.
    Masana, Luis
    Descamps, Olivier S.
    Wiklund, Olov
    Hegele, Robert A.
    Raal, Frederick J.
    Defesche, Joep C.
    Wiegman, Albert
    Santos, Raul D.
    Watts, Gerald F.
    Parhofer, Klaus G.
    Hovingh, G. Kees
    Kovanen, Petri T.
    Boileau, Catherine
    Averna, Maurizio
    Boren, Jan
    Bruckert, Eric
    Catapano, Alberico L.
    Kuivenhoven, Jan Albert
    Pajukanta, Paeivi
    Ray, Kausik
    Stalenhoef, Anton F. H.
    Stroes, Erik
    Taskinen, Marja-Riitta
    Tybjaerg-Hansen, Anne
    [J]. EUROPEAN HEART JOURNAL, 2013, 34 (45) : 3478 - +
  • [8] New metrics needed to visualize the long-term impact of early LDL-C lowering on the cardiovascular disease trajectory
    Packard, Chris J.
    Weintraub, William S.
    Laufs, Ulrich
    [J]. VASCULAR PHARMACOLOGY, 2015, 71 : 37 - 39
  • [9] PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial
    Raal, Frederick J.
    Stein, Evan A.
    Dufour, Robert
    Turner, Traci
    Civeira, Fernando
    Burgess, Lesley
    Langslet, Gisle
    Scott, Russell
    Olsson, Anders G.
    Sullivan, David
    Hovingh, G. Kees
    Cariou, Bertrand
    Gouni-Berthold, Ioanna
    Somaratne, Ransi
    Bridges, Ian
    Scott, Rob
    Wasserman, Scott M.
    Gaudet, Daniel
    [J]. LANCET, 2015, 385 (9965) : 331 - 340
  • [10] Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)
    Schulz, Rainer
    Schlueter, Klaus-Dieter
    Laufs, Ulrich
    [J]. BASIC RESEARCH IN CARDIOLOGY, 2015, 110 (02)