Simplified algorithm to facilitate communication of familial hypercholesterolaemia

被引：12

作者：

Laufs, Ulrich ^{[1
]}

Parhofer, Klaus G. ^{[2
]}

机构：

[1] Univ Klinikum Saarlandes, Klin Innere Med Kardiol Angiol & Internist Intens, D-66421 Homburg, Germany

[2] Klinikum Univ Munchen, Med Klin 2, Munich, Germany

来源：

EUROPEAN HEART JOURNAL | 2015年 / 36卷 / 43期

关键词：

DENSITY-LIPOPROTEIN CHOLESTEROL; SUBTILISIN/KEXIN TYPE 9; CORONARY-HEART-DISEASE; MONOCLONAL-ANTIBODY; CONTROLLED-TRIAL; AMG; 145; PCSK9;

D O I：

10.1093/eurheartj/ehv441

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：3004 / 3006

页数：3

共 15 条

[1] Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease A Mendelian Randomization Analysis [J].

Ference, Brian A. ;

Yoo, Wonsuk ;

Alesh, Issa ;

Mahajan, Nitin ;

Mirowska, Karolina K. ;

Mewada, Abhishek ;

Kahn, Joel ;

Afonso, Luis ;

Williams, Kim Allan, Sr. ;

Flack, John M. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (25) :2631-2639

[2] Genetic screening protocol for familial hypercholesterolemia which includes splicing defects gives an improved mutation detection rate [J].

Graham, CA ;

McIlhatton, BP ;

Kirk, CW ;

Beattie, ED ;

Lyttle, K ;

Hart, P ;

Neely, RDG ;

Young, IS ;

Nicholls, DP .

ATHEROSCLEROSIS, 2005, 182 (02) :331-340

[3] A molecular genetic service for diagnosing individuals with familial hypercholesterolaemia (FH) in the United Kingdom [J].

Heath, KE ;

Humphries, SE ;

Middleton-Price, H ;

Boxer, M .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2001, 9 (04) :244-252

[4] Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9 [J].

Jonathan, C ;

Pertsemlidis, A ;

Kotowski, IK ;

Graham, R ;

Christine, KG ;

Garcia, CK ;

Hobbs, HH .

NATURE GENETICS, 2005, 37 (02) :161-165

[5] ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia [J].

Kastelein, John J. P. ;

Ginsberg, Henry N. ;

Langslet, Gisle ;

Hovingh, G. Kees ;

Ceska, Richard ;

Dufour, Robert ;

Blom, Dirk ;

Civeira, Fernando ;

Krempf, Michel ;

Lorenzato, Christelle ;

Zhao, Jian ;

Pordy, Robert ;

Baccara-Dinet, Marie T. ;

Gipe, Daniel A. ;

Geiger, Mary Jane ;

Farnier, Michel .

EUROPEAN HEART JOURNAL, 2015, 36 (43) :2996-3003

[6] Familial Hypercholesterolemia: Developments in Diagnosis and Treatment [J].

Klose, Gerald ;

Laufs, Ulrich ;

Maerz, Winfried ;

Windler, Eberhard .

DEUTSCHES ARZTEBLATT INTERNATIONAL, 2014, 111 (31-32) :523-+

[7] Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease [J].

Nordestgaard, Borge G. ;

Chapman, M. John ;

Humphries, Steve E. ;

Ginsberg, Henry N. ;

Masana, Luis ;

Descamps, Olivier S. ;

Wiklund, Olov ;

Hegele, Robert A. ;

Raal, Frederick J. ;

Defesche, Joep C. ;

Wiegman, Albert ;

Santos, Raul D. ;

Watts, Gerald F. ;

Parhofer, Klaus G. ;

Hovingh, G. Kees ;

Kovanen, Petri T. ;

Boileau, Catherine ;

Averna, Maurizio ;

Boren, Jan ;

Bruckert, Eric ;

Catapano, Alberico L. ;

Kuivenhoven, Jan Albert ;

Pajukanta, Paeivi ;

Ray, Kausik ;

Stalenhoef, Anton F. H. ;

Stroes, Erik ;

Taskinen, Marja-Riitta ;

Tybjaerg-Hansen, Anne .

EUROPEAN HEART JOURNAL, 2013, 34 (45) :3478-+

[8] New metrics needed to visualize the long-term impact of early LDL-C lowering on the cardiovascular disease trajectory [J].

Packard, Chris J. ;

Weintraub, William S. ;

Laufs, Ulrich .

VASCULAR PHARMACOLOGY, 2015, 71 :37-39

[9] PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial [J].

Raal, Frederick J. ;

Stein, Evan A. ;

Dufour, Robert ;

Turner, Traci ;

Civeira, Fernando ;

Burgess, Lesley ;

Langslet, Gisle ;

Scott, Russell ;

Olsson, Anders G. ;

Sullivan, David ;

Hovingh, G. Kees ;

Cariou, Bertrand ;

Gouni-Berthold, Ioanna ;

Somaratne, Ransi ;

Bridges, Ian ;

Scott, Rob ;

Wasserman, Scott M. ;

Gaudet, Daniel .

LANCET, 2015, 385 (9965) :331-340

[10] Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9) [J].

Schulz, Rainer ;

Schlueter, Klaus-Dieter ;

Laufs, Ulrich .

BASIC RESEARCH IN CARDIOLOGY, 2015, 110 (02)

← 1 2 →