Molecular and epigenetic modes of Fumonisin B1 mediated toxicity and carcinogenesis and detoxification strategies

被引:14
作者
Arumugam, Thilona [1 ]
Ghazi, Terisha [1 ]
Chuturgoon, Anil A. [1 ]
机构
[1] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Discipline Med Biochem, Durban, South Africa
基金
新加坡国家研究基金会;
关键词
Fusarium; mycotoxins; fumonisin B-1; toxicity; oxidative stress; ER stress; immunotoxicity; epigenetics; mycotoxin detoxification; CERAMIDE SYNTHASE INHIBITION; OXIDATIVE STRESS; FUSARIUM-MONILIFORME; SPHINGOLIPID BIOSYNTHESIS; ENDOPLASMIC-RETICULUM; ESOPHAGEAL CANCER; DNA METHYLATION; AFLATOXIN B-1; MYCOTOXIN CONTAMINATION; INFLAMMATORY CYTOKINES;
D O I
10.1080/10408444.2021.1881040
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Fumonisin B-1 (FB1) is a natural contaminant of agricultural commodities that has displayed a myriad of toxicities in animals. Moreover, it is known to be a hepatorenal carcinogen in rodents and may be associated with oesophageal and hepatocellular carcinomas in humans. The most well elucidated mode of FB1-mediated toxicity is its disruption of sphingolipid metabolism; however, enhanced oxidative stress, endoplasmic reticulum stress, autophagy, and alterations in immune response may also play a role in its toxicity and carcinogenicity. Alterations to the host epigenome may impact on the toxic and carcinogenic response to FB1. Seeing that the contamination of FB1 in food poses a considerable risk to human and animal health, a great deal of research has focused on new methods to prevent and attenuate FB1-induced toxic consequences. The focus of the present review is on the molecular and epigenetic interactions of FB1 as well as recent research involving FB1 detoxification.
引用
收藏
页码:76 / 94
页数:19
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