Alpha-synuclein and presynaptic function - Implications for Parkinson's disease

被引:27
|
作者
Lykkebo, S [1 ]
Jensen, PH [1 ]
机构
[1] Aarhus Univ, Dept Biochem Med, DK-8000 Aarhus C, Denmark
关键词
synuclein; synapse; axon; vesicles; Parkinson's disease; Lewy body;
D O I
10.1385/NMM:2:2:115
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This article focuses on alpha-synuclein's role in normal and pathological axonal and presynaptic functions and its relationship to Parkinson's disease. It is not possible to mention all the contributions to aspects of this area. Readers interested in alpha-synuclein's relation to aggregation, Lewy lesions, and pathological modifications are referred to the many reviews (see Goldberg and Lansbury 2000; Galvin 2001a; Goedert 2001).
引用
收藏
页码:115 / 129
页数:15
相关论文
共 50 条
  • [1] Alpha-synuclein and presynaptic functionImplications for Parkinson’s disease
    Simon Lykkebo
    Poul Henning Jensen
    NeuroMolecular Medicine, 2002, 2 : 115 - 129
  • [2] Advances in understanding the function of alpha-synuclein: implications for Parkinson's disease
    Calabresi, Paolo
    Di Lazzaro, Giulia
    Marino, Gioia
    Campanelli, Federica
    Ghiglieri, Veronica
    BRAIN, 2023, 146 (09) : 3587 - 3597
  • [3] Presynaptic Alpha-Synuclein Aggregation in a Mouse Model of Parkinson's Disease
    Spinelli, Kateri J.
    Taylor, Jonathan K.
    Osterberg, Valerie R.
    Churchill, Madeline J.
    Pollock, Eden
    Moore, Cynthia
    Meshul, Charles K.
    Unni, Vivek K.
    JOURNAL OF NEUROSCIENCE, 2014, 34 (06): : 2037 - 2050
  • [4] The Convergence of Dopamine and alpha-Synuclein: Implications for Parkinson's Disease
    Mor, Danielle E.
    Ischiropoulos, Harry
    JOURNAL OF EXPERIMENTAL NEUROSCIENCE, 2018, 12
  • [5] Alpha-Synuclein Nitration and Its Implications in Parkinson's Disease
    He, Yixi
    Yu, Zhongwang
    Chen, Shengdi
    ACS CHEMICAL NEUROSCIENCE, 2019, 10 (02): : 777 - +
  • [6] Alpha-synuclein and Parkinson's disease
    Golbe, LI
    MOVEMENT DISORDERS, 1999, 14 (01) : 6 - 9
  • [7] Alpha-synuclein and Parkinson's disease
    C. B. Lücking
    A. Brice*
    Cellular and Molecular Life Sciences CMLS, 2000, 57 : 1894 - 1908
  • [8] Alpha-synuclein and Parkinson's disease
    Lücking, CB
    Brice, A
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2000, 57 (13-14) : 1894 - 1908
  • [9] Accumulation of presynaptic proteinase K-resistant alpha-synuclein in Parkinson's disease
    Tanji, Kunikazu
    Mori, Fumiaki
    Kakita, Akiyoshi
    Takahashi, Hitoshi
    Wakabayashi, Koichi
    NEUROSCIENCE RESEARCH, 2010, 68 : E192 - E192
  • [10] Alpha-synuclein, lipids and Parkinson's disease
    Ruiperez, Violeta
    Darios, Frederic
    Davletov, Bazbek
    PROGRESS IN LIPID RESEARCH, 2010, 49 (04) : 420 - 428