Chronic Infection With Camelid Hepatitis E Virus in a Liver Transplant Recipient Who Regularly Consumes Camel Meat and Milk

被引：447

作者：

Lee, Guan-Huei ^{[1
,3
,5
]}

Tan, Boon-Huan ^{[2
]}

Teo, Esmeralda Chi-Yuan ^{[6
]}

Lim, Seng-Gee ^{[1
,3
,5
]}

Dan, Yock-Young ^{[1
,3
,5
]}

Wee, Aileen ^{[1
,4
]}

Aw, Pauline Poh Kim ^{[8
]}

Zhu, Yuan ^{[8
]}

Hibberd, Martin Lloyd ^{[8
,9
]}

Tan, Chee-Kiat ^{[7
,10
]}

Purdy, Michael A. ^{[11
]}

Teo, Chong-Gee ^{[11
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117595, Singapore

[2] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore

[3] Natl Univ Hlth Syst, Dept Med, Singapore, Singapore

[4] Natl Univ Hlth Syst, Dept Pathol, Singapore, Singapore

[5] Natl Univ Singapore Hosp, Natl Univ Ctr Organ Transplantat, Singapore, Singapore

[6] Singapore Gen Hosp, Dept Hematol, Singapore, Singapore

[7] Singapore Gen Hosp, Dept Gastroenterol & Hepatol, Singapore, Singapore

[8] Genome Inst Singapore, Singapore, Singapore

[9] London Sch Hyg & Trop Med, London WC1, England

[10] Duke NUS Grad Med Sch, Singapore, Singapore

[11] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA

来源：

GASTROENTEROLOGY | 2016年 / 150卷 / 02期

关键词：

Case Study; Liver Disease; Zoonosis; Viral Infection; EPIDEMIOLOGY;

D O I：

10.1053/j.gastro.2015.10.048

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There have been increasing reports of food-borne zoonotic transmission of hepatitis E virus (HEV) genotype 3, which causes chronic infections in immunosuppressed patients. We performed phylogenetic analyses of the HEV sequence (partial and full-length) from 1 patient from the Middle East who underwent liver transplantation, and compared it with other orthohepevirus A sequences. We found the patient to be infected by camelid HEV. This patient regularly consumed camel meat and milk, therefore camelid HEV, which is genotype 7, might infect human beings. Our finding links consumption of camel-derived food products to post-transplantation hepatitis E, which, if detected at early stages, can be cured with antiviral therapy and reduced administration of immunosuppressive agents.

引用

页码：355 / +

页数：6

共 11 条

[1]

Aw PPK, 2014, METHODS MOL BIOL, V1138, P175, DOI 10.1007/978-1-4939-0348-1_12

[2] The Camel today: assets and potentials [J].

Faye, Bernard .

ANTHROPOZOOLOGICA, 2014, 49 (02) :167-176

[3] Hepatitis E virus and chronic hepatitis in organ-transplant recipients. [J].

Kamar, Nassim ;

Selves, Janick ;

Mansuy, Jean-Michel ;

Ouezzani, Leila ;

Peron, Jean-Marie ;

Guitard, Joelle ;

Cointault, Olivier ;

Esposito, Laure ;

Abravanel, Florence ;

Danjoux, Marie ;

Durand, Dominique ;

Vinel, Jean-Pierre ;

Izopet, Jacques ;

Rostaing, Lionel .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (08) :811-817

[4] Hepatitis E Virus and Neurologic Disorders [J].

Kamar, Nassim ;

Bendall, Richard P. ;

Peron, Jean Marie ;

Cintas, Pascal ;

Prudhomme, Laurent ;

Mansuy, Jean Michel ;

Rostaing, Lionel ;

Keane, Frances ;

Ijaz, Samreen ;

Izopet, Jacques ;

Dalton, Harry R. .

EMERGING INFECTIOUS DISEASES, 2011, 17 (02) :173-179

[5] Sero-prevalence and mother-to-infant transmission of hepatitis E virus among pregnant women in the United Arab Emirates [J].

Kumar, RM ;

Uduman, S ;

Rana, S ;

Kochiyil, JK ;

Usmani, A ;

Thomas, L .

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2001, 100 (01) :9-15

[6] Clustal W and clustal X version 2.0 [J].

Larkin, M. A. ;

Blackshields, G. ;

Brown, N. P. ;

Chenna, R. ;

McGettigan, P. A. ;

McWilliam, H. ;

Valentin, F. ;

Wallace, I. M. ;

Wilm, A. ;

Lopez, R. ;

Thompson, J. D. ;

Gibson, T. J. ;

Higgins, D. G. .

BIOINFORMATICS, 2007, 23 (21) :2947-2948

[7]

Purdy MA, ICTV TAXONOMIC PROPO

[8]

Tamura K, 2013, MOL BIOL EVOL, V30, P2725, DOI [10.1093/molbev/mst197, 10.1093/molbev/msr121]

[9] Much meat, much malady: changing perceptions of the epidemiology of hepatitis E [J].

Teo, C. G. .

CLINICAL MICROBIOLOGY AND INFECTION, 2010, 16 (01) :24-32

[10] New Hepatitis E Virus Genotype in Camels, the Middle East [J].

Woo, Patrick C. Y. ;

Lau, Susanna K. P. ;

Teng, Jade L. L. ;

Tsang, Alan K. L. ;

Joseph, Marina ;

Wong, Emily Y. M. ;

Tang, Ying ;

Sivakumar, Saritha ;

Xie, Jun ;

Bai, Ru ;

Wernery, Renate ;

Wernery, Ulrich ;

Yuen, Kwok-Yung .

EMERGING INFECTIOUS DISEASES, 2014, 20 (06) :1044-1048

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