Ganglioside complexes as new target antigens in Guillain-Barre syndrome

被引：110
作者：
Kaida, K
Morita, D
Kanzaki, M
Kamakura, K
Motoyoshi, K
Hirakawa, M
Kusunoki, S
机构：
[1] Kinki Univ, Sch Med, Dept Neurol, Osaka 5898511, Japan
[2] Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama, Japan
来源：
ANNALS OF NEUROLOGY | 2004年 / 56卷 / 04期
关键词：
D O I：
10.1002/ana.20222
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Antibodies specific for a complex of gangliosides GD1a and GD1b (GD1a/GD1b) were found in sera from eight of 100 patients with Guillain-Barre syndrome (GBS) by the use of enzyme-linked immunosorbent assay and thin-layer chromatogram immunostaining. Those sera also had antibody activities to such ganglioside complexes as GD1a/GM1, GD1b/GT1b, and GM1/GT1b but had little or no reactivity to the each isolated antigen. Clustered epitopes of the ganglioside complex in the plasma membrane may be targeted by such an antibody, and interaction between the antibody and ganglioside complex may induce the neuropathy.
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页码：567 / 571
页数：5
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