Multifunctional Magnetoplasmonic Nanoparticle Assemblies for Cancer Therapy and Diagnostics (Theranostics)

被引:77
作者
Chen, Wei [1 ,2 ]
Xu, Naifeng [1 ]
Xu, Liguang [1 ]
Wang, Libing [1 ]
Li, Zuokun [1 ]
Ma, Wei [1 ]
Zhu, Yingyue [1 ]
Xu, Chuanlai [1 ]
Kotov, Nicholas A. [2 ]
机构
[1] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
[2] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA
基金
美国国家科学基金会;
关键词
corona-like assemblies; curcumin; leukemia; magnetic gold NPs; NP assemblies; NP superstructures; theranostics; IRON-OXIDE NANOPARTICLES; MAGNETIC NANOPARTICLES; GOLD NANOPARTICLES; FE3O4-AT-SIO2; CORE; SHELL; RESONANCE; PARTICLES; NANOCOMPOSITES; LUMINESCENT; AGENTS;
D O I
10.1002/marc.200900793
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
In this work, we describe the preparation and biomedical functionalities of complex nanoparticle assemblies with magnetoplasmonic properties suitable for simultaneous cancer therapy and diagnostics (theranostics). Most commonly magnetoplasmonic nanostructures are made by careful adaptation of metal reduction protocols which is both tedious and restrictive. Here we apply the strategy of nanoscale assemblies to prepare such systems from individual building blocks. The prepared superstructures are based on magnetic Fe3O4 nanoparticles encapsulated in silica shell representing the magnetic module. The cores are surrounded in a corona-like fashion by gold nanoparticles representing the plasmonic module. As additional functionality they were also coated by poly(ethyleneglycol) chains as a cloaking agent to extend the blood circulation time. The preparation is exceptionally simple and allows one to vary the contribution of each function. Both modules can carry drugs and, in this study, they were loaded with the potential anticancer drug curcumin. A comprehensive set of microscopy, spectroscopy and biochemical methods were applied to characterize both imaging and therapeutic function of the nanoparticle assemblies against leukemia HL-60 cells. High contrast magnetic resonance images and high apoptosis rates demonstrate the success of assembly approach for the preparation of magnetoplasmonic nanoparticles. This technology allows one to easily "dial in" the functionalities in the clinical setting for personalized theranostic regiments.
引用
收藏
页码:228 / 236
页数:9
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