Multifunctional Magnetoplasmonic Nanoparticle Assemblies for Cancer Therapy and Diagnostics (Theranostics)

被引:76
作者
Chen, Wei [1 ,2 ]
Xu, Naifeng [1 ]
Xu, Liguang [1 ]
Wang, Libing [1 ]
Li, Zuokun [1 ]
Ma, Wei [1 ]
Zhu, Yingyue [1 ]
Xu, Chuanlai [1 ]
Kotov, Nicholas A. [2 ]
机构
[1] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
[2] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA
基金
美国国家科学基金会;
关键词
corona-like assemblies; curcumin; leukemia; magnetic gold NPs; NP assemblies; NP superstructures; theranostics; IRON-OXIDE NANOPARTICLES; MAGNETIC NANOPARTICLES; GOLD NANOPARTICLES; FE3O4-AT-SIO2; CORE; SHELL; RESONANCE; PARTICLES; NANOCOMPOSITES; LUMINESCENT; AGENTS;
D O I
10.1002/marc.200900793
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
In this work, we describe the preparation and biomedical functionalities of complex nanoparticle assemblies with magnetoplasmonic properties suitable for simultaneous cancer therapy and diagnostics (theranostics). Most commonly magnetoplasmonic nanostructures are made by careful adaptation of metal reduction protocols which is both tedious and restrictive. Here we apply the strategy of nanoscale assemblies to prepare such systems from individual building blocks. The prepared superstructures are based on magnetic Fe3O4 nanoparticles encapsulated in silica shell representing the magnetic module. The cores are surrounded in a corona-like fashion by gold nanoparticles representing the plasmonic module. As additional functionality they were also coated by poly(ethyleneglycol) chains as a cloaking agent to extend the blood circulation time. The preparation is exceptionally simple and allows one to vary the contribution of each function. Both modules can carry drugs and, in this study, they were loaded with the potential anticancer drug curcumin. A comprehensive set of microscopy, spectroscopy and biochemical methods were applied to characterize both imaging and therapeutic function of the nanoparticle assemblies against leukemia HL-60 cells. High contrast magnetic resonance images and high apoptosis rates demonstrate the success of assembly approach for the preparation of magnetoplasmonic nanoparticles. This technology allows one to easily "dial in" the functionalities in the clinical setting for personalized theranostic regiments.
引用
收藏
页码:228 / 236
页数:9
相关论文
共 51 条
  • [1] Synthesis of Magnetic Fe2O3/Au Core/Shell Nanoparticles for Bioseparation and Immunoassay Based on Surface-Enhanced Raman Spectroscopy
    Bao, Fang
    Yao, Jian-Lin
    Gu, Ren-Ao
    [J]. LANGMUIR, 2009, 25 (18) : 10782 - 10787
  • [2] Nanoparticles in cancer therapy and diagnosis
    Brigger, I
    Dubernet, C
    Couvreur, P
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) : 631 - 651
  • [3] Discrete Functional Gold Nanoparticles: Hydrogen Bond-Assisted Synthesis, Magnetic Purification, Supramolecular Dimer and Trimer Formation
    Chak, Chun-Pong
    Xuan, Shouhu
    Mendes, Paula M.
    Yu, Jimmy C.
    Cheng, Christopher H. K.
    Leung, Ken Cham-Fai
    [J]. ACS NANO, 2009, 3 (08) : 2129 - 2138
  • [4] Inhibition of telomerase activity and induction of apoptosis by curcurnin in K-562 cells
    Chakraborty, S
    Ghosh, U
    Bhattacharyya, NP
    Bhattacharya, RK
    Roy, M
    [J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2006, 596 (1-2) : 81 - 90
  • [5] Gastrin Releasing Protein Receptor Specific Gold Nanorods: Breast and Prostate Tumor Avid Nanovectors for Molecular Imaging
    Chanda, Nripen
    Shukla, Ravi
    Katti, Kattesh V.
    Kannan, Raghuraman
    [J]. NANO LETTERS, 2009, 9 (05) : 1798 - 1805
  • [6] Superparamagnetic high-magnetization microspheres with an Fe3O4@SiO2 core and perpendicularly aligned mesoporous SiO2 shell for removal of microcystins
    Deng, Yonghui
    Qi, Dawei
    Deng, Chunhui
    Zhang, Xiangmin
    Zhao, Dongyuan
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (01) : 28 - +
  • [7] High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system
    Eghtedari, Mohammad
    Oraevsky, Alexander
    Copland, John A.
    Kotov, Nicholas A.
    Conjusteau, Andre
    Motamedi, Massoud
    [J]. NANO LETTERS, 2007, 7 (07) : 1914 - 1918
  • [8] Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles
    El-Sayed, Ivan H.
    Huang, Xiaohua
    El-Sayed, Mostafa A.
    [J]. CANCER LETTERS, 2006, 239 (01) : 129 - 135
  • [9] ESBEN KUL, 2009, ACS NANO, V3, P1947
  • [10] Fabrication and Dispersion of Gold-Shell-Protected Magnetite Nanoparticles: Systematic Control Using Polyethyleneimine
    Goon, Ian Y.
    Lai, Leo M. H.
    Lim, May
    Munroe, Paul
    Gooding, J. Justin
    Amal, Rose
    [J]. CHEMISTRY OF MATERIALS, 2009, 21 (04) : 673 - 681