In this work, we describe the preparation and biomedical functionalities of complex nanoparticle assemblies with magnetoplasmonic properties suitable for simultaneous cancer therapy and diagnostics (theranostics). Most commonly magnetoplasmonic nanostructures are made by careful adaptation of metal reduction protocols which is both tedious and restrictive. Here we apply the strategy of nanoscale assemblies to prepare such systems from individual building blocks. The prepared superstructures are based on magnetic Fe3O4 nanoparticles encapsulated in silica shell representing the magnetic module. The cores are surrounded in a corona-like fashion by gold nanoparticles representing the plasmonic module. As additional functionality they were also coated by poly(ethyleneglycol) chains as a cloaking agent to extend the blood circulation time. The preparation is exceptionally simple and allows one to vary the contribution of each function. Both modules can carry drugs and, in this study, they were loaded with the potential anticancer drug curcumin. A comprehensive set of microscopy, spectroscopy and biochemical methods were applied to characterize both imaging and therapeutic function of the nanoparticle assemblies against leukemia HL-60 cells. High contrast magnetic resonance images and high apoptosis rates demonstrate the success of assembly approach for the preparation of magnetoplasmonic nanoparticles. This technology allows one to easily "dial in" the functionalities in the clinical setting for personalized theranostic regiments.
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Chinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
Chak, Chun-Pong
Xuan, Shouhu
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Chinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
Xuan, Shouhu
Mendes, Paula M.
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Univ Birmingham, Sch Chem Engn, Coll Engn & Phys Sci, Birmingham B15 2TT, W Midlands, EnglandChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
Mendes, Paula M.
Yu, Jimmy C.
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Chinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
Yu, Jimmy C.
Cheng, Christopher H. K.
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Chinese Univ Hong Kong, Dept Biochem Med, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
Cheng, Christopher H. K.
Leung, Ken Cham-Fai
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Chinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
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Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
El-Sayed, Ivan H.
Huang, Xiaohua
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机构:Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
Huang, Xiaohua
El-Sayed, Mostafa A.
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机构:Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
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Univ New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
Goon, Ian Y.
Lai, Leo M. H.
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Univ New S Wales, Sch Chem, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
Lai, Leo M. H.
Lim, May
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Univ New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
Lim, May
Munroe, Paul
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Univ New S Wales, Electron Microscope Unit, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
Munroe, Paul
Gooding, J. Justin
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Univ New S Wales, Sch Chem, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
Gooding, J. Justin
Amal, Rose
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Univ New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
机构:
Chinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
Chak, Chun-Pong
Xuan, Shouhu
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h-index: 0
机构:
Chinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
Xuan, Shouhu
Mendes, Paula M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Birmingham, Sch Chem Engn, Coll Engn & Phys Sci, Birmingham B15 2TT, W Midlands, EnglandChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
Mendes, Paula M.
Yu, Jimmy C.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
Yu, Jimmy C.
Cheng, Christopher H. K.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Dept Biochem Med, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
Cheng, Christopher H. K.
Leung, Ken Cham-Fai
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Dept Chem, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
El-Sayed, Ivan H.
Huang, Xiaohua
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
Huang, Xiaohua
El-Sayed, Mostafa A.
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h-index: 0
机构:Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
机构:
Univ New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
Goon, Ian Y.
Lai, Leo M. H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Chem, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
Lai, Leo M. H.
Lim, May
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
Lim, May
Munroe, Paul
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Electron Microscope Unit, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
Munroe, Paul
Gooding, J. Justin
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Chem, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia
Gooding, J. Justin
Amal, Rose
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, AustraliaUniv New S Wales, ARC Ctr Excellence Funct Nanomat, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia