A deficiency in the B cell response of C57BL/6 mice correlates with loss of macrophage-mediated killing of Leishmania amazonensis

被引：13
|
作者：
Gibson-Corley, Katherine N. [1 ]
Boggiatto, Paola M. [1 ]
Mukbel, Rami M. [1 ]
Petersen, Christine A. [1 ]
Jones, Douglas E. [1 ]
机构：
[1] Iowa State Univ, Dept Vet Pathol, Coll Vet Med, Ames, IA 50011 USA
来源：
INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2010年 / 40卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Cutaneous leishmaniasis; Murine model; Co-infection; B cells; Macrophages; FC-RECEPTOR; INFECTION; SUSCEPTIBILITY; AMASTIGOTES; ANTIBODIES;
D O I：
10.1016/j.ijpara.2009.11.010
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Infection of C3HeB/FeJ and C57BL/6 mice with Leishmania major stimulates a healing cell-mediated immune response, while Leishmania amazonensis infection leads to chronic disease. Here we show C3HeB/FeJ mice co-infected with both species of Leishmania heal, while co-infected C57BL/6 mice do not. Using an in vitro killing assay we determined B cells from infected C57BL/6 mice are ineffective in promoting parasite killing compared with B cells from infected C3HeB/FeJ mice. Furthermore, infected C57BL/6 mice produce less antigen-specific antibodies compared with infected C3HeB/FeJ mice. These findings Suggest B cells play a required role in the cell-mediated immune response against L. amazonensis. (C) 2009 Australian Society for Parasitology Inc. All rights reserved.
引用
收藏
页码：157 / 161
页数：5
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