Platelets Are Critical Key Players in Sepsis

被引：152

作者：

Vardon-Bounes, Fanny ^{[1
,2
]}

Ruiz, Stephanie ^{[1
]}

Gratacap, Marie-Pierre ^{[2
]}

Garcia, Cedric ^{[3
]}

Payrastre, Bernard ^{[2
,3
]}

Minville, Vincent ^{[1
,2
]}

机构：

[1] Toulouse Univ Hosp, Anesthesiol & Crit Care Unit, F-31059 Toulouse, France

[2] Toulouse Univ Hosp, INSERM, Inst Malad Cardiovasc & Metabol I2MC, UMR 1048, F-31059 Toulouse, France

[3] Toulouse Univ Hosp, Hematol Lab, F-31059 Toulouse, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 14期

关键词：

platelets; sepsis; endothelium; immunothrombosis; NEUTROPHIL EXTRACELLULAR TRAPS; INTENSIVE-CARE-UNIT; STAPHYLOCOCCUS-AUREUS; ILL PATIENTS; PHOSPHOINOSITIDE; 3-KINASE; THROMBOCYTOPENIA; ACTIVATION; HISTONES; RECEPTOR; PI3K-BETA;

D O I：

10.3390/ijms20143494

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet pathogens interactions. The critical role of platelets during sepsis and the therapeutic implications are also reviewed.

引用

页数：13

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