One-Pot Reductive N-Alkylation with Carbonyl Compounds To Give Tertiary Amines via Borane Reduction of Imines

被引：16
|
作者：
Tokizane, Masashi [2 ]
Sato, Kaori [2 ]
Sakami, Yuki [2 ]
Imori, Yoichiro [2 ]
Matsuo, Chika [2 ]
Ohta, Tetsuo [1 ]
Ito, Yoshihiko [2 ]
机构：
[1] Doshisha Univ, Fac Life & Med Sci, Dept Biomed Informat, Kyoto 6100394, Japan
[2] Doshisha Univ, Fac Engn, Dept Mol Sci & Technol, Kyoto 6100394, Japan
来源：
SYNTHESIS-STUTTGART | 2010年 / 01期
关键词：
reductive N-alkylation; borane reduction; imines; tertiary amines; one-pot reaction; SECONDARY-AMINES; AMINATION; ALDEHYDES; KETONES; COMPLEX; REAGENTS; PYRIDINE; SOLVENT;
D O I：
10.1055/s-0029-1217076
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One-pot synthesis of tertiary amines via borane-mediated reduction of imines and reductive N-alkylation with carbonyl compounds is described. This protocol's reducing agent is only borane in the reduction of imines, and additional reductant is not necessary in reductive N-alkylation step. When using more than two equivalents of aldehydes, reductive N-alkylation proceeded in good yield.
引用
收藏
页码：36 / 42
页数：7
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