Adalimumab treatment for life threatening pulmonary artery aneurysm in Behcet disease: a case report

被引：37

作者：

Lee, Sung-Won ^{[1
]}

Lee, Sang-Yeob ^{[1
]}

Kim, Ki-Nam ^{[2
]}

Jung, Jin-Kyu ^{[1
]}

Chung, Won-Tae ^{[1
]}

机构：

[1] Dong A Univ, Coll Med, Dept Internal Med, Pusan, South Korea

[2] Dong A Univ, Coll Med, Dept Radiol, Pusan, South Korea

来源：

CLINICAL RHEUMATOLOGY | 2010年 / 29卷 / 01期

关键词：

Adalimumab; Beh sigma et disease; Pulmonary artery aneurysm; TNF-alpha inhibitor; VASCULAR INVOLVEMENT;

D O I：

10.1007/s10067-009-1272-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Beh sigma et's disease (BD) is a multisystem disorder characterized by vasculitis. Pulmonary vascular problems such as pulmonary artery aneurysms (PAA) are reported to indicate poor prognosis and high mortality. We describe a 43-year-old man who presented with life threatening bilateral PAA and thromboembolic disease due to BD. He was treated with prednisone and pulse cyclophosphamide and was poorly responsive to the conventional immunosuppression. The introduction of adalimumab therapy stabilized his PAA. We report that the inhibition of TNF-alpha using the neutralizing monoclonal antibody adalimumab has the potential to induce rapid, complete, and long-lasting remission in a life-threatening manifestation of BD.

引用

页码：91 / 93

页数：3

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