Immunotherapy for cancer in the central nervous system: Current and future directions

被引：46

作者：

Binder, David C. ^{[1
,2
]}

Davis, Andrew A. ^{[3
]}

Wainwright, Derek A. ^{[4
]}

机构：

[1] Univ Chicago, Commitee Canc Biol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[3] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Northwestern Univ, Feinberg Sch Med, Dept Neurol Surg, Chicago, IL 60611 USA

来源：

ONCOIMMUNOLOGY | 2016年 / 5卷 / 02期

关键词：

Brain metastases; glioblastoma; glioma; IDO; T cell therapy; vaccination; NEWLY-DIAGNOSED GLIOBLASTOMA; GROWTH-FACTOR RECEPTOR; DENDRITIC CELL VACCINATION; FIXED TUMOR VACCINE; LONG-TERM SURVIVAL; REGULATORY T-CELLS; PHASE I/IIA TRIAL; HIGH-GRADE GLIOMA; ANTITUMOR IMMUNITY; CTLA-4; BLOCKADE;

D O I：

10.1080/2162402X.2015.1082027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and still remains incurable. Although immunotherapeutic vaccination against GBM has demonstrated immune-stimulating activity with some promising survival benefits, tumor relapse is common, highlighting the need for additional and/or combinatorial approaches. Recently, antibodies targeting immune checkpoints were demonstrated to generate impressive clinical responses against advanced melanoma and other malignancies, in addition to showing potential for enhancing vaccination and radiotherapy (RT). Here, we summarize the current knowledge of central nervous system (CNS) immunosuppression, evaluate past and current immunotherapeutic trials and discuss promising future immunotherapeutic directions to treat CNS-localized malignancies.

引用

页数：15

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