Regulatory pathways involved in the infection-induced production of IFN-γ by NK cells

被引：68
|
作者：
Lieberman, LA [1 ]
Hunter, CA [1 ]
机构：
[1] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
来源：
MICROBES AND INFECTION | 2002年 / 4卷 / 15期
基金：
美国国家卫生研究院;
关键词：
NK cell; IFN-gamma; pathogen; infection; Stat4; IL-12; innate immunity;
D O I：
10.1016/S1286-4579(02)00036-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The production of interferon gamma (IFN-gamma) by natural killer (NK) cells provides an innate mechanism of resistance to many intracellular pathogens. These events are regulated by multiple cytokines and transcription factors which have both positive and negative effects. This article reviews the role of cytokines, as well as costimulatory and signaling pathways, involved in NK cell responses associated with resistance to infection. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：1531 / 1538
页数：8
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