The role of Bach1 in the induction of heme oxygenase by tin mesoporphyrin

被引：22

作者：

Abate, Aida ^{[1
]}

Zhao, Hui ^{[1
]}

Wong, Ronald J. ^{[1
]}

Stevenson, David K. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 354卷 / 03期

关键词：

Bach1; heme oxygenase; isozymes; metalloporphyrins; tin mesoporphyrin;

D O I：

10.1016/j.bbrc.2007.01.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tin mesoporphyrin (SnMP), a competitive heme oxygenase (HO) inhibitor, also induces HO-1 mRNA and protein expression by a mechanism that is not fully understood. We examined whether the induction by SnMP is mediated by a de-repression of Bach1, a transcription factor that suppresses the HO-1 gene. Incubation of NIH3T3-HO-1-luc cells with SnMP attenuated HO activity with a concomitant increase in HO-1 mRNA and protein and a decrease in Bach1 and HO-2 proteins, which was not due to transcriptional down-regulation, but accelerated protein decay. Similarly, HO-1 protein degradation was increased by SnMP, despite of an elevation in HO-1 transcription. Transfection of Bach1 shRNA in Hepa cells raised basal HO-1 expression significantly, and SnMP treatment further increased HO-1 mRNA. In conclusion, SnMP induces HO-1 expression not only by de-repressing the HO-I promoter by binding Bach1, but also by accelerating Bach1 degradation. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：757 / 763

页数：7

共 22 条

[1] Apigenin decreases hemin-mediated heme oxygenase-1 induction [J].

Abate, A ;

Yang, G ;

Wong, RJ ;

Schroder, H ;

Stevenson, DK ;

Dennery, PA .

FREE RADICAL BIOLOGY AND MEDICINE, 2005, 39 (06) :711-718

[2]

Alam J, 2004, ANTIOXID REDOX SIGN, V6, P924, DOI 10.1089/ars.2004.6.924

[3] Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway [J].

Alam, J ;

Cook, JL .

CURRENT PHARMACEUTICAL DESIGN, 2003, 9 (30) :2499-2511

[4] Differences in basal and hyperoxia-associated HO expression in oxidant-resistant hamster fibroblasts [J].

Dennery, PA ;

Wong, HE ;

Sridhar, KJ ;

Rodgers, PA ;

Sim, JE ;

Spitz, DR .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1996, 271 (04) :L672-L679

[5] The effectiveness of oral tin mesoporphyrin prophylaxis in reducing bilirubin production after an oral heme load in a transgenic mouse model [J].

DeSandre, GH ;

Wong, RJ ;

Morioka, I ;

Contag, CH ;

Stevenson, DK .

BIOLOGY OF THE NEONATE, 2006, 89 (03) :139-146

[6] Effects of Metalloporphyrins on Heme Oxygenase-1 Transcription: Correlative Cell Culture Assays Guide In Vivo Imaging [J].

Hajdena-Dawson, Monica ;

Zhang, Weisheng ;

Contag, Pamela R. ;

Wong, Ronald J. ;

Vreman, Hendrik J. ;

Stevenson, David K. ;

Contag, Christopher H. .

Molecular Imaging, 2003, 2 (03) :138-149

[7] Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain [J].

Itoh, K ;

Wakabayashi, N ;

Katoh, Y ;

Ishii, T ;

Igarashi, K ;

Engel, JD ;

Yamamoto, M .

GENES & DEVELOPMENT, 1999, 13 (01) :76-86

[8] The heme oxygenase system: A regulator of second messenger gases [J].

Maines, MD .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1997, 37 :517-554

[9] Systemic effects of orally-administered zinc and tin (IV) metalloporphyrins on heme oxygenase expression in mice [J].

Morioka, I ;

Wong, RJ ;

Abate, A ;

Vreman, HJ ;

Contag, CH ;

Stevenson, DK .

PEDIATRIC RESEARCH, 2006, 59 (05) :667-672

[10] MECHANISMS OF ENDOTOXIN-INDUCED HEME OXYGENASE MESSENGER-RNA ACCUMULATION IN MOUSE-LIVER - SYNERGISM BY GLUTATHIONE DEPLETION AND PROTECTION BY N-ACETYLCYSTEINE [J].

RIZZARDINI, M ;

CARELLI, M ;

PORRAS, MRC ;

CANTONI, L .

BIOCHEMICAL JOURNAL, 1994, 304 :477-483

← 1 2 3 →