Transition Metal-Free Iodosobenzene-Promoted Direct Oxidative 3-Arylation of Quinoxalin-2(H)-ones with Arylhydrazines

被引:145
作者
Paul, Sanjay [1 ]
Ha, Ji Hyeon [1 ]
Park, Ga Eul [1 ]
Lee, Yong Rok [1 ]
机构
[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 712749, South Korea
基金
新加坡国家研究基金会;
关键词
arylhydrazines; benzo[g]quinoxalinones; iodosylbenzene (PHIO)-promoted reaction; pyrido[3; 4-b]pyrazinones; transition metal-free oxidative arylation; ALDOSE REDUCTASE INHIBITORS; TERT-BUTYL HYDROPEROXIDE; QUINOXALINONE DERIVATIVES; POLYVALENT IODINE; DIRECT ARYLATION; BOND FORMATION; QUINOXALIN-2(1H)-ONES; CHEMISTRY; ENAMINES; CYCLIZATION;
D O I
10.1002/adsc.201700070
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A transition metal-free iodosobenzene-promoted direct oxidative 3-arylation of quinoxalin-2(H)-ones was developed using various arylhydrazines under air. The protocol affords a variety of 3-arylquinoxalin-2(H)-one derivatives in moderate to good yields. This method provides a rapid access to biologically interesting benzo[g]quinoxalinones and pyrido[3,4-b]pyrazinones. The present methodology features high functional group tolerance including base-sensitive groups as well as allyl- and benzyl-substituted quinoxalin-2(H)-ones under mild reaction conditions.
引用
收藏
页码:1515 / 1521
页数:7
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