Synthesis of mulberry leaf extract mediated gold nanoparticles and their ameliorative effect on Aluminium intoxicated and diabetic retinopathy in rats during perinatal life

被引：23
作者：
Xu, Lishuai [1 ,2 ,3 ]
Li, Weidong [4 ]
Shi, Qian [5 ]
Li, Heng [6 ]
Yang, Zhen [3 ]
Liao, Dan [3 ]
Li, Linrui [3 ]
Yang, Xiaoli [2 ,3 ]
Zhang, Junjun [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Ophthalmol, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
[2] North Sichuan Med Coll, Dept Ophthalmol & Optometry, Nanchong 637000, Sichuan, Peoples R China
[3] North Sichuan Med Coll, Affiliated Hosp, Dept Ophthalmol, Nanchong 637000, Sichuan, Peoples R China
[4] North Sichuan Med Coll, Affiliated Hosp, Dept Cardiol, Nanchong 637000, Sichuan, Peoples R China
[5] Yixing Eye Hosp, Dept Ophthalmol, Yixing 214200, Jiangsu, Peoples R China
[6] Suining Cent Hosp, Dept Ophthalmol, Suining 629000, Sichuan, Peoples R China
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2019年 / 196卷
关键词：
Retinopathy; AgNPs; Mulberry; Biomolecules; SILVER NANOPARTICLES; MITOCHONDRIAL DYSFUNCTION; RETINA; OXIDE;
D O I：
10.1016/j.jphotobiol.2019.04.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present report showed the green synthesis of Silver nanoparticles (AgNPs) using Mulberry leaf extract via an environment friendly approach and investigated to know the probable ameliorative effect via biochemical assessment on retinopathy of rats that are maternally subjected to Al intoxication and diabetes. Mulberry leaf extract biomolecules act as capping and reducing agent for fabrication of AgNPs. Later, the fabricated AgNPs were characterized by using spectroscopic and microscopic instrumental techniques such as HR-TEM, UV-Vis, XRD and FT-IR. EDS, XRD and TEM have confirmed the synthesis of AgNPs. HRTEM results exhibited that the formed AgNPs are polydispersed and spherical in nature with mean particle size of 35 nm. Microscopic observation of retina in Al-intoxicated and diabetic mother rats showed abnormal changes in retinal cell layers. Yet, the retina of rats that are maternally received AgNPs plus diabetes or Al-intoxicated exhibited noticeable amelioration. However, lower ameliorations were found in rat's retina that are maternally undergone for combined exposure. Additionally, biochemical assessment revealed that the application of AgNPs caused the amelioration of the changes in Al concentration and maternal serum glucose. The present study revealed that AgNPs are active against diabetic and Aluminium-persuaded developmental retinopathy.
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页数：6
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