Phosphatase-triggered guest release from a cyclodextrin complex

被引:19
作者
Cho, A
Lara, KLO
Yatsimirsky, AK [1 ]
Eliseev, AV
机构
[1] SUNY Buffalo, Dept Med Chem, Buffalo, NY 14260 USA
[2] UAEM, Fac Ciencias, Cuernavaca 62210, Morelos, Mexico
[3] Natl Autonomous Univ Mexico, Fac Quim, Mexico City 04510, DF, Mexico
关键词
D O I
10.1021/ol005915x
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] A synthetic supramolecular system is described that models the effect of phosphoryl transfer in molecular recognition. beta-Cyclodextrin-6A-phosphate (pCD), which is shown to be a substrate of alkaline phosphatase, binds cationic aromatic guests, including anticancer agents, up to 100-fold better than native beta-CD. The above observations demonstrate that pCD is capable of releasing the guests from its cavity upon hydrolysis with the phosphatase, as also confirmed by monitoring the hydrolysis in the presence of a guest.
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页码:1741 / 1743
页数:3
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