Macrophage polarization by phytotherapy in the tumor microenvironment

被引：13
作者：
Saeedifar, Amir Mohammad [1 ]
Mosayebi, Ghasem [1 ,2 ]
Ghazavi, Ali [1 ,3 ]
Bushehri, Rouhollah Hemmati [1 ]
Ganji, Ali [1 ,2 ]
机构：
[1] Arak Univ Med Sci, Sch Med, Dept Immunol & Microbiol, Arak, Iran
[2] Arak Univ Med Sci, Mol & Med Res Ctr, Arak, Iran
[3] Arak Univ Med Sci, Tradit & Complementary Med Res Ctr TCMRC, Arak, Iran
来源：
PHYTOTHERAPY RESEARCH | 2021年 / 35卷 / 07期
关键词：
macrophage polarization; phytotherapy; signaling pathways; tumor; GLIOBLASTOMA CELL-PROLIFERATION; MOLECULAR-MECHANISMS; SIGNAL TRANSDUCER; CHLOROGENIC ACID; DENDRITIC CELLS; OVARIAN-CANCER; M2; PHENOTYPE; BETA-ELEMENE; IN-VITRO; KAPPA-B;
D O I：
10.1002/ptr.7058
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several signaling pathways were involved in M1 (classic) and M2 (alternative) macrophage polarization. Disruption of M2-related signaling pathways and improvement of M1-related signaling pathways can be identified as one of the cancer therapeutic approaches. Prevention of macrophage differentiation into M2 by different herbal agents with antitumor properties can be considered as a promising therapeutic target for cancer patients. In the present review study, we investigated the effect of herbal compounds on M1 and M2 related signaling pathways to reduce M2 and increase M1 macrophage polarization for the treatment of different types of cancer.
引用
收藏
页码：3632 / 3648
页数：17
相关论文
共 112 条
  • [1] Adarsh C., 2015, RES J AGR FORESTRY S, V2320, P6063
  • [2] Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy
    Albini, Adriana
    Bruno, Antonino
    Noonan, Douglas M.
    Mortara, Lorenzo
    [J]. FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [3] Characterization of M1/M2 Tumour-Associated Macrophages (TAMs) and Th1/Th2 Cytokine Profiles in Patients with NSCLC
    Almatroodi, S. A.
    McDonald, C. F.
    Darby, I. A.
    Pouniotis, D. S.
    [J]. CANCER MICROENVIRONMENT, 2016, 9 (01) : 1 - 11
  • [4] STAT3 inhibition specifically in human monocytes and macrophages by CD163-targeted corosolic acid-containing liposomes
    Andersen, Morten Norgaard
    Etzerodt, Anders
    Graversen, Jonas H.
    Holthof, Lisa C.
    Moestrup, Soren K.
    Hokland, Marianne
    Moller, Holger J.
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2019, 68 (03) : 489 - 502
  • [5] ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute myeloid leukemia
    Basappa, Johnvesly
    Citir, Mevlut
    Zhang, Qian
    Wang, Hong Y.
    Liu, Xiaobin
    Melnikov, Olga
    Yahya, Hafiz
    Stein, Frank
    Muller, Rainer
    Traynor-Kaplan, Alexis
    Schultz, Carsten
    Wasik, Mariusz A.
    Ptasznik, Andrzej
    [J]. HELIYON, 2020, 6 (05)
  • [6] Macrophage polarization in bacterial infections
    Benoit, Marie
    Desnues, Benoit
    Mege, Jean-Louis
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 181 (06) : 3733 - 3739
  • [7] Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis
    Bertani, Francesca R.
    Mozetic, Pamela
    Fioramonti, Marco
    Iuliani, Michele
    Ribelli, Giulia
    Pantano, Francesco
    Santini, Daniele
    Tonini, Giuseppe
    Trombetta, Marcella
    Businaro, Luca
    Selci, Stefano
    Rainer, Alberto
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [8] Regulation of M1/M2 macrophage polarization by Sutherlandia frutescens via NFkB and MAPK signaling pathways
    Camille, N.
    Dealtry, G.
    [J]. SOUTH AFRICAN JOURNAL OF BOTANY, 2018, 116 : 42 - 51
  • [9] Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth
    Cao, Meng
    Yan, Huaijiang
    Han, Xuan
    Weng, Ling
    Wei, Qin
    Sun, Xiaoyan
    Lu, Wuguang
    Wei, Qingyun
    Ye, Juan
    Cai, Xueting
    Hu, Chunping
    Yin, Xiaoyang
    Cao, Peng
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7 (01):
  • [10] Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets
    Cassetta, Luca
    Fragkogianni, Stamatina
    Sims, Andrew H.
    Swierczak, Agnieszka
    Forrester, Lesley M.
    Zhang, Hui
    Soong, Daniel Y. H.
    Cotechini, Tiziana
    Anur, Pavane
    Lin, Elaine Y.
    Fidanza, Antonella
    Lopez-Yrigoyen, Martha
    Millar, Michael R.
    Urman, Alexandra
    Ai, Zhichao
    Spellman, Paul T.
    Hwang, E. Shelley
    Dixon, J. Michael
    Wiechmann, Lisa
    Coussens, Lisa M.
    Smith, Harriet O.
    Pollard, Jeffrey W.
    [J]. CANCER CELL, 2019, 35 (04) : 588 - +
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