Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19

被引：46

作者：

Aamodt, Anne Hege ^{[1
]}

Hogestol, Einar August ^{[1
,2
]}

Popperud, Trine Haug ^{[1
]}

Holter, Jan Cato ^{[2
,3
]}

Dyrhol-Riise, Anne Ma ^{[2
,4
]}

Tonby, Kristian ^{[2
,4
]}

Stiksrud, Birgitte ^{[4
]}

Quist-Paulsen, Else ^{[3
]}

Berge, Tone ^{[5
,6
]}

Barratt-Due, Andreas ^{[7
,8
]}

Aukrust, Pal ^{[2
,8
,9
]}

Heggelund, Lars ^{[10
,11
]}

Blennow, Kaj ^{[12
,13
]}

Zetterberg, Henrik ^{[13
,14
,15
]}

Harbo, Hanne Flinstad ^{[1
,2
]}

机构：

[1] Oslo Univ Hosp, Dept Neurol, Oslo, Norway

[2] Univ Oslo, Inst Clin Med, Oslo, Norway

[3] Oslo Univ Hosp, Dept Microbiol, Oslo, Norway

[4] Oslo Univ Hosp, Dept Infect Dis, Oslo, Norway

[5] Oslo Metropolitan Univ, Dept Mech Elect & Chem Engn, Oslo, Norway

[6] Oslo Univ Hosp, Dept Res Innovat & Educ, Oslo, Norway

[7] Oslo Univ Hosp, Div Emergencies & Crit Care, Rigshosp, Oslo, Norway

[8] Oslo Univ Hosp, Dept Immunol, Oslo, Norway

[9] Oslo Univ Hosp, Res Inst Internal Med, Oslo, Norway

[10] Vestre Viken Hosp Trust, Drammen Hosp, Dept Internal Med, Drammen, Norway

[11] Univ Bergen, Dept Clin Sci, Bergen, Norway

[12] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden

[13] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[14] UCL Inst Neurol, Dept Neurodegenerat Dis, London, England

[15] UCL, UK Dementia Res Inst, London, England

来源：

JOURNAL OF NEUROLOGY | 2021年 / 268卷 / 10期

基金：

英国医学研究理事会;

关键词：

SARS-CoV-2; COVID-19; Neurofilament light; Glial fibrillary acidic protein; Mortality; TRAUMATIC BRAIN-INJURY; BIOMARKER;

D O I：

10.1007/s00415-021-10517-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for disease severity in COVID-19 patients. Methods Forty-seven inpatients with confirmed COVID-19 had blood samples drawn on admission for assessing serum biomarkers of CNS injury by Single molecule array (Simoa), NfL and GFAp. Concentrations of NfL and GFAp were analyzed in relation to symptoms, clinical signs, inflammatory biomarkers and clinical outcomes. We used multivariate linear models to test for differences in biomarker concentrations in the subgroups, accounting for confounding effects. Results In total, 21% (n = 10) of the patients were admitted to an intensive care unit, and the overall mortality rate was 13% (n = 6). Non-survivors had higher serum concentrations of NfL (p < 0.001) upon admission than patients who were discharged alive both in adjusted analyses (p = 2.6 x 10(-7)) and unadjusted analyses (p = 0.001). The concentrations of NfL in non-survivors increased over repeated measurements; whereas, the concentrations in survivors were stable. The GFAp concentration was also significantly higher in non-survivors than survivors (p = 0.02). Conclusion Increased concentrations of NfL and GFAp in COVID-19 patients on admission may indicate increased mortality risk. Measurement of blood biomarkers for nervous system injury can be useful to detect and monitor CNS injury in COVID-19.

引用

页码：3574 / 3583

页数：10

共 26 条

[1]

Aamodt AH, 2020, TIDSSKR NORSKE LAEGE, V140, P968

[2] Prolonged Cerebrospinal Fluid Neurofilament Light Chain Increase in Patients with Post-Traumatic Disorders of Consciousness [J].