Dynamic risk control by human nucleus accumbens

被引：12

作者：

Nachev, Parashkev ^{[1
]}

Lopez-Sosa, Fernando ^{[2
]}

Jesus Gonzalez-Rosa, Javier ^{[2
]}

Galarza, Ana ^{[2
]}

Avecillas, Josue ^{[3
]}

Angel Pineda-Pardo, Jose ^{[4
,5
]}

Jose Lopez-Ibor, Juan ^{[6
]}

Reneses, Blanca ^{[6
]}

Antonio Barcia, Juan ^{[3
]}

Strange, Bryan ^{[2
]}

机构：

[1] UCL, Inst Neurol, London, England

[2] Tech Univ Madrid, Ctr Biomed Technol, Lab Clin Neurosci, Madrid, Spain

[3] Univ Complutense Madrid, Inst Invest Sanitaria San Carlos, Hosp Clin San Carlos, Dept Neurosurg, Madrid, Spain

[4] Hosp Madrid, HM Puerta Sur, CINAC, Mostoles, Spain

[5] CEU San Pablo Univ, Madrid, Spain

[6] Univ Complutense Madrid, Inst Invest Sanitaria San Carlos, Hosp Clin San Carlos, Dept Psychiat, Madrid, Spain

来源：

BRAIN | 2015年 / 138卷

基金：

英国惠康基金;

关键词：

nucleus accumbens; risk; reward; decision-making; subcortical electrical stimulation; OBSESSIVE-COMPULSIVE-DISORDER; DEEP BRAIN-STIMULATION; DECISION-MAKING; AVERSION; REWARD;

D O I：

10.1093/brain/awv285

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Real-world decisions about reward often involve a complex counterbalance of risk and value. Although the nucleus accumbens has been implicated in the underlying neural substrate, its criticality to human behaviour remains an open question, best addressed with interventional methodology that probes the behavioural consequences of focal neural modulation. Combining a psychometric index of risky decision-making with transient electrical modulation of the nucleus accumbens, here we reveal profound, highly dynamic alteration of the relation between probability of reward and choice during therapeutic deep brain stimulation in four patients with treatment-resistant psychiatric disease. Short-lived phasic electrical stimulation of the region of the nucleus accumbens dynamically altered risk behaviour, transiently shifting the psychometric function towards more risky decisions only for the duration of stimulation. A critical, on-line role of human nucleus accumbens in dynamic risk control is thereby established.

引用

页码：3496 / 3502

页数：7