Microwave enhanced palladium catalysed coupling reactions: A diversity-oriented synthesis approach to functionalised flavones

被引：45
作者：
Fitzmaurice, Richard J.
Etheridge, Zac C.
Jumel, Emelie
Woolfson, Derek N.
Caddick, Stephen
机构：
[1] UCL, Dept Chem, Christopher Ingold Labs, London WC1H 0AJ, England
[2] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
[3] Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England
来源：
CHEMICAL COMMUNICATIONS | 2006年 / 46期
关键词：
D O I：
10.1039/b610734f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microwave enhanced diversity-oriented synthesis (MEDOS) using palladium catalysed protocols is introduced as a powerful new strategy for the synthesis of systematically modified small molecules and is highlighted by application to functionalised flavones.
引用
收藏
页码：4814 / 4816
页数：3
相关论文
共 31 条
[1]   A CONVENIENT LARGE-SCALE SYNTHESIS OF 5-METHOXYFLAVONE AND ITS APPLICATION TO ANALOG PREPARATION [J].
ARES, JJ ;
OUTT, PE ;
KAKODKAR, SV ;
BUSS, RC ;
GEIGER, JC .
JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (27) :7903-7905
[2]   Molecular rearrangement of some o-acyloxyacetophenones and the mechanism of the production of 3-acylchromones [J].
Baker, W .
JOURNAL OF THE CHEMICAL SOCIETY, 1933, :1381-1389
[3]   Fast synthesis of aryl triflates with controlled microwave heating [J].
Bengtson, A ;
Hallberg, A ;
Larhed, M .
ORGANIC LETTERS, 2002, 4 (07) :1231-1233
[4]   Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation [J].
Bennett, CJ ;
Caldwell, ST ;
McPhail, DB ;
Morrice, PC ;
Duthie, GG ;
Hartley, RC .
BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (09) :2079-2098
[5]   Synthetic ligands for apo-neocarzinostatin [J].
Caddick, S ;
Muskett, FW ;
Stoneman, RG ;
Woolfson, DN .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (13) :4204-4205
[6]   Synthesis and biological evaluation of flavonoids as vasorelaxant agents [J].
Chen, ZW ;
Hu, YZ ;
Wu, HH ;
Jiang, HD .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (15) :3949-3952
[7]  
Cipák L, 2003, LEUKEMIA RES, V27, P65, DOI 10.1016/S0145-2126(02)00063-2
[8]   A METHOD FOR THE FACILE SYNTHESIS OF RING-A HYDROXYLATED FLAVONES [J].
CUSHMAN, M ;
NAGARATHNAM, D .
TETRAHEDRON LETTERS, 1990, 31 (45) :6497-6500
[9]   Synthesis and biological activities of 8-arylflavones [J].
Dao, TT ;
Kim, SB ;
Sin, KS ;
Kim, S ;
Kim, HP ;
Park, H .
ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (03) :278-282
[10]  
Deng BL, 1999, EUR J ORG CHEM, V1999, P2683
1234