Microwave enhanced palladium catalysed coupling reactions: A diversity-oriented synthesis approach to functionalised flavones

被引:45
作者
Fitzmaurice, Richard J.
Etheridge, Zac C.
Jumel, Emelie
Woolfson, Derek N.
Caddick, Stephen
机构
[1] UCL, Dept Chem, Christopher Ingold Labs, London WC1H 0AJ, England
[2] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
[3] Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England
关键词
D O I
10.1039/b610734f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Microwave enhanced diversity-oriented synthesis (MEDOS) using palladium catalysed protocols is introduced as a powerful new strategy for the synthesis of systematically modified small molecules and is highlighted by application to functionalised flavones.
引用
收藏
页码:4814 / 4816
页数:3
相关论文
共 31 条
  • [1] A CONVENIENT LARGE-SCALE SYNTHESIS OF 5-METHOXYFLAVONE AND ITS APPLICATION TO ANALOG PREPARATION
    ARES, JJ
    OUTT, PE
    KAKODKAR, SV
    BUSS, RC
    GEIGER, JC
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (27) : 7903 - 7905
  • [2] Molecular rearrangement of some o-acyloxyacetophenones and the mechanism of the production of 3-acylchromones
    Baker, W
    [J]. JOURNAL OF THE CHEMICAL SOCIETY, 1933, : 1381 - 1389
  • [3] Fast synthesis of aryl triflates with controlled microwave heating
    Bengtson, A
    Hallberg, A
    Larhed, M
    [J]. ORGANIC LETTERS, 2002, 4 (07) : 1231 - 1233
  • [4] Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation
    Bennett, CJ
    Caldwell, ST
    McPhail, DB
    Morrice, PC
    Duthie, GG
    Hartley, RC
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (09) : 2079 - 2098
  • [5] Synthetic ligands for apo-neocarzinostatin
    Caddick, S
    Muskett, FW
    Stoneman, RG
    Woolfson, DN
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (13) : 4204 - 4205
  • [6] Synthesis and biological evaluation of flavonoids as vasorelaxant agents
    Chen, ZW
    Hu, YZ
    Wu, HH
    Jiang, HD
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (15) : 3949 - 3952
  • [7] Cipák L, 2003, LEUKEMIA RES, V27, P65, DOI 10.1016/S0145-2126(02)00063-2
  • [8] A METHOD FOR THE FACILE SYNTHESIS OF RING-A HYDROXYLATED FLAVONES
    CUSHMAN, M
    NAGARATHNAM, D
    [J]. TETRAHEDRON LETTERS, 1990, 31 (45) : 6497 - 6500
  • [9] Synthesis and biological activities of 8-arylflavones
    Dao, TT
    Kim, SB
    Sin, KS
    Kim, S
    Kim, HP
    Park, H
    [J]. ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (03) : 278 - 282
  • [10] Deng BL, 1999, EUR J ORG CHEM, V1999, P2683