Nitric oxide dysfunction in vascular endothelium and platelets: role in essential hypertension

被引:68
|
作者
Gkaliagkousi, Eugenia [1 ,2 ]
Douma, Stella [2 ]
Zamboulis, Chrysanthos [2 ]
Ferro, Albert [1 ]
机构
[1] Kings Coll London, Dept Clin Pharmacol, Div Cardiovasc, London SE1 9NH, England
[2] Aristotle Univ Thessaloniki, Prop Dept Med 2, GR-54006 Thessaloniki, Greece
关键词
endothelium; essential hypertension; nitric oxide; platelets; MONOMETHYL-L-ARGININE; BLOOD-FLOW RESPONSES; CARDIOVASCULAR RISK-FACTORS; DEPENDENT VASODILATION; RELAXING FACTOR; ASYMMETRIC DIMETHYLARGININE; MOLECULAR-CLONING; BRACHIAL-ARTERY; SYNTHASE GENE; ACCELERATED ATHEROSCLEROSIS;
D O I
10.1097/HJH.0b013e328330e89a
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Both endothelial and platelet-derived nitric oxide have important vasculoprotective properties. Increasing evidence suggests a dysfunctional platelet nitric oxide synthase type 3 (NOS3) pathway in essential hypertension, whereas for endothelial-derived nitric oxide the picture is more complicated, with many studies suggesting an impairment of endothelial nitric oxide generation, whilst others have suggested that the endothelial nitric oxide pathway is preserved. Controversy also exists as to whether any observed reduction in endothelial or platelet-derived nitric oxide exerts a pathogenetic role or is simply the result of the raised blood pressure. In this review, we examine the evidence that endothelial and/or platelet-derived nitric oxide are disturbed in essential hypertension, and whether such disturbances are cause or effect. J Hypertens 27:2310-2320 (c) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:2310 / 2320
页数:11
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