Shared and divergent neurocognitive impairments in adult patients with schizophrenia and bipolar disorder: Whither the evidence?

被引:39
作者
Kuswanto, Carissa [1 ]
Chin, Rowena [1 ]
Sum, Min Yi [1 ]
Sengupta, Somnath [2 ]
Fagiolini, Andrea [3 ]
McIntyre, Roger S. [4 ]
Vieta, Eduard [5 ]
Sim, Kang [1 ,2 ]
机构
[1] Inst Mental Hlth, Div Res, 10 Buangkok View, Singapore 539747, Singapore
[2] Woodbridge Hosp, Inst Mental Hlth, Dept Gen Psychiat, 10 Buangkok View, Singapore 539747, Singapore
[3] Univ Siena, Div Psychiat, Dept Mol Med, Viale Bracci 1, I-53100 Siena, Italy
[4] Univ Toronto, Univ Hlth Network, Mood Disorders Psychopharmacol Unit, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada
[5] Univ Barcelona, Inst Neurosci, Hosp Clin, Bipolar Disorders Program,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain
关键词
Neurocognitive impairments; Schizophrenia; Bipolar disorder; CONSENSUS COGNITIVE BATTERY; GENOME-WIDE ASSOCIATION; I DISORDER; NEUROPSYCHOLOGICAL FUNCTION; SCHIZOAFFECTIVE DISORDER; 1ST-EPISODE PSYCHOSIS; EXECUTIVE FUNCTION; MEMORY IMPAIRMENT; REPEATABLE BATTERY; MAJOR PSYCHOSES;
D O I
10.1016/j.neubiorev.2015.12.002
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Recent data from genetic and brain imaging studies have urged rethinking of bipolar disorder (BD) and schizophrenia (SCZ) as lying along a continuum of major endogenous psychoses rather than dichotomous disorders. We systematically reviewed extant studies (from January 2000 to July 2015) that directly compared neurocognitive impairments in adults with SCZ and BD. Within 36 included studies, comparable neurocognitive impairments were found in SCZ and BD involving executive functioning, working memory, verbal fluency and motor speed. The extent and severity of neurocognitive impairments in patients with schizoaffective disorder, and BD with psychotic features occupy positions intermediate between SCZ and BD without psychotic features, suggesting spectrum of neurocognitive impairments across psychotic spectrum conditions. Neurocognitive impairments correlated with socio-demographic (lower education), clinical (more hospitalizations, longer duration of illness, negative psychotic symptoms and non-remission status), treatment (antipsychotics, anti-cholinergics) variables and lower psychosocial functioning. The convergent neurocognitive findings in both conditions support a continuum concept of psychotic disorders and further research is needed to clarify common and dissimilar progression of specific neurocognitive impairments longitudinally. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:66 / 89
页数:24
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