DNA interaction and antioxidant studies of ruthenium(II) complexes containing mixed ligands

被引：1
|
作者：
Sampath, Krishnan [1 ]
Mohanraj, Maruthachalam [2 ]
Jayabalakrishnan, Chinnasamy [2 ]
机构：
[1] Kumaraguru Coll Technol, Dept Chem, Coimbatore, Tamil Nadu, India
[2] Sri Ramakrishna Mission Vidyalaya Coll Arts & Sci, Post Grad & Res Dept Chem, Coimbatore 641020, Tamil Nadu, India
来源：
INORGANIC AND NANO-METAL CHEMISTRY | 2017年 / 47卷 / 07期
关键词：
Ruthenium(II) complexes; benzothiazole; DNA binding; DNA cleavage; antioxidants; IN-VITRO; CYTOTOXIC ACTIVITIES; ANTIFUNGAL ACTIVITY; CRYSTAL-STRUCTURES; SCHIFF-BASES; BINDING; TRIPHENYLPHOSPHINE; CLEAVAGE; TERNARY; DESIGN;
D O I：
10.1080/24701556.2017.1284089
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Ruthenium(II) complexes of mixed ligands (benzothiazolyl Schiff base, PPh3, and AsPh3) have been synthesized. Structural features of the ligands and complexes were determined by various physicochemical and spectral techniques. In order to ascertain the potential of the above-synthesized compounds towards biomolecular interactions, titration experiments involving interaction with calf thymus DNA (CT-DNA) were carried out. A gel electrophoresis pictogram demonstrated the ability of the complexes to cleave the CT-DNA. The ligands and complexes have shown significant antioxidant activity.
引用
收藏
页码：1049 / 1056
页数：8
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