Are Midsagittal Tissue Bridges Predictive of Outcome After Cervical Spinal Cord Injury?

被引：53
|
作者：
Huber, Eveline [1 ]
Lachappelle, Patrice [1 ]
Sutter, Reto [2 ]
Curt, Armin [1 ]
Freund, Patrick [1 ,3 ,4 ,5 ]
机构：
[1] Balgrist Univ Hosp, Spinal Cord Injury Ctr, Forchstr 340, CH-8008 Zurich, Switzerland
[2] Balgrist Univ Hosp, Radiol, Zurich, Switzerland
[3] UCL, Inst Neurol, Wellcome Trust Ctr Neuroimaging, London, England
[4] UCL, UCL Inst Neurol, Dept Brain Repair & Rehabil, London, England
[5] Max Planck Inst Human Cognit & Brain Sci, Dept Neurophys, Leipzig, Germany
来源：
ANNALS OF NEUROLOGY | 2017年 / 81卷 / 05期
关键词：
CONTUSION; RECOVERY; MR; REGENERATION; SYSTEM; LESION; RAT;
D O I：
10.1002/ana.24932
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
T-2-weighted scans provided data on the extent and dynamics of neuronal tissue damage and midsagittal tissue bridges at the epicenter of traumatic cervical spinal cord lesions in 24 subacute tetraplegic patients. At 1 month postinjury, smaller lesion area and midsagittal tissue bridges identified those patients with lower extremity evoked potentials and better clinical recovery. Wider midsagittal tissue bridges and smaller lesions at 1 month post-injury were associated with neurological and functional recovery at 1-year follow-up. Neuroimaging biomarkers of lesion size and midsagittal tissue bridges are potential outcome predictors and patient stratifiers in both subacute and chronic clinical trials.
引用
收藏
页码：740 / 748
页数：9
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