'Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19

被引：568

作者：

Mandal, Swapna ^{[1
]}

Barnett, Joseph ^{[2
]}

Brill, Simon E. ^{[1
]}

Brown, Jeremy S. ^{[3
,4
]}

Denneny, Emma K. ^{[4
]}

Hare, Samanjit S. ^{[2
]}

Heightman, Melissa ^{[4
]}

Hillman, Toby E. ^{[4
]}

Jacob, Joseph ^{[5
,6
]}

Jarvis, Hannah C. ^{[1
]}

Lipman, Marc C., I ^{[1
,3
]}

Naidu, Sindhu B. ^{[1
]}

Nair, Arjun ^{[6
]}

Porter, Joanna C. ^{[3
,4
]}

Tomlinson, Gillian S. ^{[4
,7
]}

Hurst, John R. ^{[1
,3
]}

机构：

[1] Royal Free London NHS Fdn Trust, Resp Med, London, England

[2] Royal Free London NHS Fdn Trust, Dept Radio, London, England

[3] UCL, UCL Resp, London NW3 2PF, England

[4] Univ Coll London Hosp NHS Fdn Trust, Resp Med, London, England

[5] UCL, Ctr Med Image Comp, London, England

[6] Univ Coll London Hosp NHS Fdn Trust, Dept Radiol, London, England

[7] UCL, Infect & Immun, London, England

来源：

THORAX | 2021年 / 76卷 / 04期

基金：

英国惠康基金;

关键词：

viral infection; respiratory infection;

D O I：

10.1136/thoraxjnl-2020-215818

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. In those discharged with elevated biomarkers, 30.1% and 9.5% had persistently elevated d-dimer and C reactive protein, respectively. 38% of chest radiographs remained abnormal with 9% deteriorating. Systematic follow-up after hospitalisation with COVID-19 identifies the trajectory of physical and psychological symptom burden, recovery of blood biomarkers and imaging which could be used to inform the need for rehabilitation and/or further investigation.

引用

页码：396 / 398

页数：3

共 7 条

[1] British Society of Thoracic Imaging, COVID 19 CHEST XRAY
[2] Persistent Symptoms in Patients After Acute COVID-19
Carfi, Angelo
Bernabei, Roberto
Landi, Francesco
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 324 (06): : 603 - 605
[3] Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation
Halpin, Stephen J.
McIvor, Claire
Whyatt, Gemma
Adams, Anastasia
Harvey, Olivia
McLean, Lyndsay
Walshaw, Christopher
Kemp, Steven
Corrado, Joanna
Singh, Rajinder
Collins, Tamsin
O'Connor, Rory J.
Sivan, Manoj
[J]. JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (02) : 1013 - 1022
[4] Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors
Hui, DS
Joynt, GM
Wong, KT
Gomersall, CD
Li, TS
Antonio, G
Ko, FW
Chan, MC
Chan, DP
Tong, MW
Rainer, TH
Ahuja, AT
Cockram, CS
Sung, JJY
[J]. THORAX, 2005, 60 (05) : 401 - 409
[5] Coagulopathy in COVID-19
Iba, Toshiaki
Levy, Jerrold H.
Levi, Marcel
Thachil, Jecko
[J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020, 18 (09) : 2103 - 2109
[6] Abnormal pulmonary function in COVID-19 patients at time of hospital discharge
Mo, Xiaoneng
Jian, Wenhua
Su, Zhuquan
Chen, Mu
Peng, Hui
Peng, Ping
Lei, Chunliang
Chen, Ruchong
Zhong, Nanshan
Li, Shiyue
[J]. EUROPEAN RESPIRATORY JOURNAL, 2020, 55 (06)
[7] Wei JP, 2020, J X-RAY SCI TECHNOL, V28, P383, DOI 10.3233/XST-200685

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