'Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19

被引：581

作者：

Mandal, Swapna ^{[1
]}

Barnett, Joseph ^{[2
]}

Brill, Simon E. ^{[1
]}

Brown, Jeremy S. ^{[3
,4
]}

Denneny, Emma K. ^{[4
]}

Hare, Samanjit S. ^{[2
]}

Heightman, Melissa ^{[4
]}

Hillman, Toby E. ^{[4
]}

Jacob, Joseph ^{[5
,6
]}

Jarvis, Hannah C. ^{[1
]}

Lipman, Marc C., I ^{[1
,3
]}

Naidu, Sindhu B. ^{[1
]}

Nair, Arjun ^{[6
]}

Porter, Joanna C. ^{[3
,4
]}

Tomlinson, Gillian S. ^{[4
,7
]}

Hurst, John R. ^{[1
,3
]}

机构：

[1] Royal Free London NHS Fdn Trust, Resp Med, London, England

[2] Royal Free London NHS Fdn Trust, Dept Radio, London, England

[3] UCL, UCL Resp, London NW3 2PF, England

[4] Univ Coll London Hosp NHS Fdn Trust, Resp Med, London, England

[5] UCL, Ctr Med Image Comp, London, England

[6] Univ Coll London Hosp NHS Fdn Trust, Dept Radiol, London, England

[7] UCL, Infect & Immun, London, England

来源：

THORAX | 2021年 / 76卷 / 04期

基金：

英国惠康基金;

关键词：

viral infection; respiratory infection;

D O I：

10.1136/thoraxjnl-2020-215818

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. In those discharged with elevated biomarkers, 30.1% and 9.5% had persistently elevated d-dimer and C reactive protein, respectively. 38% of chest radiographs remained abnormal with 9% deteriorating. Systematic follow-up after hospitalisation with COVID-19 identifies the trajectory of physical and psychological symptom burden, recovery of blood biomarkers and imaging which could be used to inform the need for rehabilitation and/or further investigation.

引用

页码：396 / 398

页数：3

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